7006-55-5Relevant academic research and scientific papers
Harnessing Thin-Film Continuous-Flow Assembly Lines
Britton, Joshua,Castle, Jared W.,Weiss, Gregory A.,Raston, Colin L.
, p. 10773 - 10776 (2016)
Inspired by nature's ability to construct complex molecules through sequential synthetic transformations, an assembly line synthesis of α-aminophosphonates has been developed. In this approach, simple starting materials are continuously fed through a thin-film reactor where the intermediates accrue molecular complexity as they progress through the flow system. Flow chemistry allows rapid multistep transformations to occur via reaction compartmentalization, an approach not amenable to using conventional flasks. Thin film processing can also access facile in situ solvent exchange to drive reaction efficiency, and through this method, α-aminophosphonate synthesis requires only 443 s residence time to produce 3.22 g h?1. Assembly-line synthesis allows unprecedented reaction flexibility and processing efficiency.
Copper-Phosphine Mediated Oxidative Phosphorylation of Aromatic Amines and P(OR)3 under Aerobic Conditions
Wang, Shihaozhi,Ma, Shidi,Yang, Jiale,Li, Wenshuang,Li, Dianjun,Yang, Jinhui
supporting information, p. 4278 - 4283 (2021/06/16)
A copper-phosphine system (Cu(OAc)2 and t-Bu3P?HBF4) was used to synthesize α-aminophosphonates and phosphoramides from various aromatic amines and trialkyl phosphites under oxygen atmosphere. With this Cu?P system, α-aminophosphonates containing C?P bonds were generated from N,N-dimethylanilines or N-methylanilines and trialkyl phosphites; phosphoramidates containing N?P bonds were produced from N-benzylanilines and trialkyl phosphites. This strategy provided a convenient and efficient method for the synthesis of phosphorous compounds. The compounds containing phosphoryl group attracted extensive attention due to their biological activities and wide applications.[1,2] The α-aminophosphonates have been applied in medicine and agriculture such as anticancer drugs, antibiotics, antibacterial agents, and enzyme inhibitors.[1] And phosphoramides could be served as antibiotics, prodrugs, flame retardants, and ligands.[2].
