70070-30-3Relevant academic research and scientific papers
Synthesis and antimicrobial activity of some 5-chloro-3-phenyl-1H-indole-2-carbonyl azide derivatives
Basavarajaiah,Mramyunjayaswamy
, p. 390 - 399 (2019/05/21)
In the present investigations, a series of new 6-substituted-3-(5-chloro-3-phenyl-lJ?-indole-2yl)-3,4-dihydro-4-substituted-4-substituted-phenacyl-2H-l,3-benzoxazin-2-one 7a-f have been synthesized by two methods making use of 5-chloro-3-phenyl-l/H-ndole-2-carbonyl azide 2 and chalcones 5a-f. In one method, compound 2 on reaction with chalcones 5a-f in presence of triethylamine in dry benzene yields respective open chain carbamates 6a-f, followed by reaction with catalytic amount of potassium hydroxide in dry benzene under reflux condition to afford compounds 7a-f. In another method, compound 5a-f on reaction with compound 2 using dry benzene in presence of catalytic amount of potassium hydroxide under reflux conditions afford cyclized products 7a-f in good yield. Structures of the all the newly synthesized compounds have been confirmed by spectral data. All these compounds have been screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, antifungal activity against Aspergillus Niger and Candida albicans and antituberculosis activity against Mycobacterium tuberculosis (H37RV).
Synthesis of Substituted 1,2,3,8-Tetrahydroindolobenzodiazepin-2-ones and 5,6,7,8-Tetrahydroindolobenzodiazepin-6-ones
Hiremath, Shivayogi P.,Badami, Prema S.,Purohit, Muralidhar G.
, p. 1115 - 1119 (2007/10/02)
Nitrosation (NaNO2/AcOH) of 2-phenylindoles (1a-d) and subsequent reduction of the resultant 3-nitroso-2-phenylindoles (2a-d) with sodium dithionite in alkali furnish the corresponding 3-aminoindoles (3a-d), which on condensation with ethyl chloroformate
Synthesis of Substituted 7H-INdoloisoquinolines
Hiremath, Shiva Yogi P.,Badami, Prema S.,Purohit, Muralidhar G.
, p. 1235 - 1238 (2007/10/02)
Various substituted ethyl 3-phenylindole-2-carbamates (4a-f) have been synthesised through the intermediacy of carboxyhydrazides (2a-f) and carboxyazides (3a-f) and converted into 5,6-dihydro-7H-indoloisoquinolin-5(6H)-ones (5a-f) by refluxing in d
Synthesis of Substituted 2-(5'-Oxo/thioxo-1',3',4'-oxodiazol-2'-yl)indoles and 2-(5'-Oxo/thioxo-1,3,4'-oxodiazol-2'-ylamino)indoles
Hiremath, Shivayogi P.,Hiremath, Dakshayani M.,Purohit, Muralidhar G.
, p. 571 - 576 (2007/10/02)
Indole-2-carboxylates (1a-i) and indole-2-carbamates (12d-i) react with hydrazine hydrate in ethanol to give the corresponding hydrazides (2a-i) and semicarbazides (13d-i).These compounds when heated under reflux with CS2 and KOH give 2-(5'-thioxo-1',3',4'-oxadiazol-2'-yl)indoles (5c,g) and 2-(5'-thioxo-1',3',4'-oxadiazol-2'-ylamino)indoles (16f,g,i).Compounds 2a-i and 13d-i undergo condensation with ethyl chloroformate to give the products 3a-g and 14d,g,h, respectively which on heating under reflux with diphenyl ether give the corresponding 2-(5'-oxo-1',3',4'-oxadiazol-2'-yl)indoles (4a-g) and 2-(5'-oxo-1',3',4'-oxadiazol-2'-ylimino)indoles (15d,g,h).Ethyl 2-phenylindole-3-carbamate (18), obtained from 3-aminoindole (17), has been condensed with hydrazine hydrate to give the semicarbazide (19) which on reation with ethyl chloroformate and heating under reflux with diphenyl ether produces 3-(5'-oxo-1',3',4'-oxadiazol-2'-ylamino)indole (21).
