70070-45-0Relevant academic research and scientific papers
Synthesis of Substituted 1,2,3,8-Tetrahydroindolobenzodiazepin-2-ones and 5,6,7,8-Tetrahydroindolobenzodiazepin-6-ones
Hiremath, Shivayogi P.,Badami, Prema S.,Purohit, Muralidhar G.
, p. 1115 - 1119 (2007/10/02)
Nitrosation (NaNO2/AcOH) of 2-phenylindoles (1a-d) and subsequent reduction of the resultant 3-nitroso-2-phenylindoles (2a-d) with sodium dithionite in alkali furnish the corresponding 3-aminoindoles (3a-d), which on condensation with ethyl chloroformate
Synthesis of Substituted 2-(5'-Oxo/thioxo-1',3',4'-oxodiazol-2'-yl)indoles and 2-(5'-Oxo/thioxo-1,3,4'-oxodiazol-2'-ylamino)indoles
Hiremath, Shivayogi P.,Hiremath, Dakshayani M.,Purohit, Muralidhar G.
, p. 571 - 576 (2007/10/02)
Indole-2-carboxylates (1a-i) and indole-2-carbamates (12d-i) react with hydrazine hydrate in ethanol to give the corresponding hydrazides (2a-i) and semicarbazides (13d-i).These compounds when heated under reflux with CS2 and KOH give 2-(5'-thioxo-1',3',4'-oxadiazol-2'-yl)indoles (5c,g) and 2-(5'-thioxo-1',3',4'-oxadiazol-2'-ylamino)indoles (16f,g,i).Compounds 2a-i and 13d-i undergo condensation with ethyl chloroformate to give the products 3a-g and 14d,g,h, respectively which on heating under reflux with diphenyl ether give the corresponding 2-(5'-oxo-1',3',4'-oxadiazol-2'-yl)indoles (4a-g) and 2-(5'-oxo-1',3',4'-oxadiazol-2'-ylimino)indoles (15d,g,h).Ethyl 2-phenylindole-3-carbamate (18), obtained from 3-aminoindole (17), has been condensed with hydrazine hydrate to give the semicarbazide (19) which on reation with ethyl chloroformate and heating under reflux with diphenyl ether produces 3-(5'-oxo-1',3',4'-oxadiazol-2'-ylamino)indole (21).
