70071-10-2

Upstream product

• 5348-42-5 4,5-Dichloro-1,2-phenylenediamine 
• 579-07-7 1-Phenylpropane-1,2-dione 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 705-60-2 1-phenyl-2-nitroprop-1-ene 
• 22596-45-8 2-methyl-2-nitro-3-phenyloxirane 
• 31378-03-7 1-phenyl-2-tosylethanone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1444302-74-2 6,7-dichloro-2-(2-fluorophenyl)-3-methylquinoxaline 
• 1420295-85-7 6,7-dichloro-3-phenylquinoxaline-2-carbaldehyde 
• 210223-16-8 7,8-Dichloro-4-phenyl-pyrrolo[1,2-a]quinoxaline-2-carboxylic acid ethyl ester 
• 210223-18-0 (7,8-Dichloro-4-phenyl-pyrrolo[1,2-a]quinoxalin-2-yl)-methanol 
• 210223-13-5 7,8-Dichloro-4-phenyl-pyrrolo[1,2-a]quinoxaline-2-carbaldehyde 

Relevant academic research and scientific papers

Discovery of 3-arylquinoxaline derivatives as potential anti-dengue virus agents

We designed and synthesized a series of novel 3-arylquinoxaline derivatives and evaluated their biological activities as potential dengue virus (DENV) replication inhibitors. Among them, [3-(4-methoxyphenyl)quinoxalin-2-yl](phenyl)methanol (19a), [6,7-dic

NH2OH-HCl-Mediated Umpolung α-Methylsulfonylation of α-Sulfonyl Ketones with Methylsulfoxides: Synthesis of α,β-Bis-sulfonyl Arylketones

In this paper, a novel and efficient route for the synthesis of α,β-bis-sulfonyl arylketones via an NH2OH-HCl-mediated intermolecular umpolung α-methylsulfonylation of α-sulfonyl ketones with methylsulfoxides is described. A plausible mechanism is proposed and discussed. Various reaction conditions for this efficient, one-pot, environmentally friendly transformation were investigated.

Ligand-Tuneable, Red-Emitting Iridium(III) Complexes for Efficient Triplet–Triplet Annihilation Upconversion Performance

A series of substituted 2-phenylquinoxaline ligands have been explored to finely tune the visible emission properties of a corresponding set of cationic, cyclometallated iridium(III) complexes. The electronic and redox properties of the complexes were investigated through experimental (including time-resolved luminescence and transient absorption spectroscopy) and theoretical methods. The complexes display absorption and phosphorescent emissions in the visible region that are attributed to metal to ligand charge-transfer transitions. The different substitution patterns of the ligands induce variations in these parameters. Time-dependent DFT studies support these assignments and show that there is likely to be a strong spin-forbidden contribution to the visible absorption bands at λ=500–600 nm. Calculations also reliably predict the magnitude and trends in triplet emitting wavelengths for the series of complexes. The complexes were assessed as potential sensitisers in triplet–triplet annihilation upconversion experiments by using 9,10-diphenylanthracene as the acceptor; the methylated variants performed especially well with impressive upconversion quantum yields of up to 39.3 %.

A highly cis-selective and enantioselective metal-free hydrogenation of 2,3-disubstituted quinoxalines

A wide range of 2,3-disubstituted quinoxalines have been successfully hydrogenated with H2 using borane catalysts to produce the desired tetrahydroquinoxalines in 80-99% yields with excellent cis selectivity. Significantly, the asymmetric reaction employing chiral borane catalysts generated by the in situ hydroboration of chiral dienes with HB(C6F5)2 under mild reaction conditions has also been achieved with up to 96% ee, and represents the first catalytic asymmetric system to furnish optically active cis-2,3-disubstituted 1,2,3,4-tetrahydroquinoxalines.

Nitroepoxides as versatile precursors to 1,4-diamino heterocycles

Nitroepoxides are easily transformed into 1,4-diamino heterocycles such as quinoxalines and pyrazines by treatment with 1,2-benzenediamines and ammonia, respectively. Additionally, related saturated heterocycles, such as piperazines and tetrahydroquinoxalines, can be accessed by treatment with 1,2-diamines and a reducing agent. These transformations are efficient, provide access privileged, bioactive structures, and produce minimal waste.

Cu(II)-catalyzed synthesis of quinoxalines from o-phenylenediamines and nitroolefins

An easy and efficient copper-catalyzed reaction for the synthesis of quinoxalines from o-phenylenediamines and nitroolefins is developed. This reaction could proceed well without additional base and be applied to various available substrates with a one-step synthetic procedure in moderate to good yields.

Synthesis of quinoxalines catalysed by cetyltrimethyl ammonium bromide (CTAB) in aqueous media

A facile and simple method has been developed for the condensation of 1,2-diaminobenzenes with α-bromoketones to form quinoxalines with good yields using cetyltrimethyl ammonium bromide (CTAB) in aqueous media. The efficiency of this reaction was demonstrated by the compatibility with nitro, methyl, methoxy, fluoro chloro bromo and furanyl groups. The important features of the methodology are broad substrate scope, simple workup, and no requirement for metal catalysts.

Synthesis of new pyrrolo[l,2-a]quinoxalines: Potential non-peptide glucagon receptor antagonists

Synthesis of new pyrrolo[1,2-a]quinoxaline derivatives was achieved starting from various nitroanilines or orthophenyle-nediamines. Their affinity towards glucagon receptors was evaluated. Elsevier, Paris.