700870-68-4

Basic information

• Product Name: Pentanoic acid, [(3R)-1-ethyl-3-piperidinyl]methyl ester (9CI)
• Synonyms: Pentanoic acid, [(3R)-1-ethyl-3-piperidinyl]methyl ester (9CI)
• CAS NO: 700870-68-4
• Molecular Formula: C13H25NO2
• Molecular Weight: 227.3431
• Product Categories: ETHYL
• Mol File: 700870-68-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pentanoic acid, [(3R)-1-ethyl-3-piperidinyl]methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, [(3R)-1-ethyl-3-piperidinyl]methyl ester (9CI)(700870-68-4)
• EPA Substance Registry System: Pentanoic acid, [(3R)-1-ethyl-3-piperidinyl]methyl ester (9CI)(700870-68-4)

Safety Data

• Hazardous Substances Data: 700870-68-4(Hazardous Substances Data)

Upstream product

• 75-07-0 acetaldehyde 
• 116574-71-1 tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 638-29-9 n-valeryl chloride 
• 144448-01-1 (S)-N-tert-butoxycarbonylpiperidin-3-ylmethyl acetate 

Relevant articles and documents

N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: A novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography

In Alzheimer's disease, cerebral cortical butyrylcholinesterase (BChE) activity is reported to be elevated. Our aim was to develop a novel 18F-labeled tracer for quantifying cerebral BChE activity by positron emission tomography. With in vitro screening of N-[14C] ethylpiperidin-3- and 4-ylmethyl esters, N-[14C]ethylpiperidin-4- ylmethyl butyrate was selected as a lead for 18F-labeling, affording N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate. The 18F-labeled butyrate showed the required properties for in vivo BChE measurement, that is, the lipophilic nature of the authentic ester, high specificity to BChE, a moderate hydrolysis rate, and the hydrophilic nature of the metabolite.