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144448-01-1

1-Piperidinecarboxylic acid, 3-[(acetyloxy)methyl]-, 1,1-dimethylethyl ester, (S)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 144448-01-1 Structure

  • Basic information

    1. Product Name: 1-Piperidinecarboxylic acid, 3-[(acetyloxy)methyl]-, 1,1-dimethylethyl ester, (S)-
    2. Synonyms:
    3. CAS NO:144448-01-1
    4. Molecular Formula: C13H23NO4
    5. Molecular Weight: 257.33
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 144448-01-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-Piperidinecarboxylic acid, 3-[(acetyloxy)methyl]-, 1,1-dimethylethyl ester, (S)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 3-[(acetyloxy)methyl]-, 1,1-dimethylethyl ester, (S)-(144448-01-1)
    11. EPA Substance Registry System: 1-Piperidinecarboxylic acid, 3-[(acetyloxy)methyl]-, 1,1-dimethylethyl ester, (S)-(144448-01-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 144448-01-1(Hazardous Substances Data)

144448-01-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 144448-01-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,4,4 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 144448-01:
(8*1)+(7*4)+(6*4)+(5*4)+(4*4)+(3*8)+(2*0)+(1*1)=121
121 % 10 = 1
So 144448-01-1 is a valid CAS Registry Number.

144448-01-1Relevant articles and documents

N-[18F]fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity

Kikuchi, Tatsuya,Zhang, Ming-Rong,Ikota, Nobuo,Fukushi, Kiyoshi,Okamura, Toshimitsu,Suzuki, Kazutoshi,Arano, Yasushi,Irie, Toshiaki

, p. 2577 - 2583 (2005)

The reduction of acetylcholinesterase (AChE) activity in the brain has been measured in dementia disorders such as Alzheimer's disease and dementia with Lewy bodies using 11C-labeled acetylcholine analogues, N-[ 11C]methylpiperidin-4-yl acetate and propionate, and positron emission tomography (PET). Our aim was to develop an 18F-labeled acetylcholine analogue useful for brain AChE mapping with PET, since 18F, with a longer half-life, has advantages over 11C. In a preliminary study, a series of N-[14C]ethylpiperidin-3-yl or -4-ylmethanol esters (acetyl and propionyl esters) were newly designed and evaluated in vitro regarding the reactivity with and specificity to AChE using purified human enzymes, leading to a novel 18F-labeled acetylcholine analogue, N-[18F]fluoroethylpiperidin-4-ylmethyl acetate. In rat experiments, the 18F-labeled candidate showed desirable properties for PET AChE measurement: high brain uptake of the authentic ester, high AChE specificity, a moderate hydrolysis rate, and low membrane permeability (metabolic trapping) of the metabolite.

N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: A novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography

Kikuchi, Tatsuya,Zhang, Ming-Rong,Ikota, Nobuo,Fukushi, Kiyoshi,Okamura, Toshimitsu,Suzuki, Kazutoshi,Arano, Yasushi,Irie, Toshiaki

, p. 1927 - 1930 (2007/10/03)

In Alzheimer's disease, cerebral cortical butyrylcholinesterase (BChE) activity is reported to be elevated. Our aim was to develop a novel 18F-labeled tracer for quantifying cerebral BChE activity by positron emission tomography. With in vitro screening of N-[14C] ethylpiperidin-3- and 4-ylmethyl esters, N-[14C]ethylpiperidin-4- ylmethyl butyrate was selected as a lead for 18F-labeling, affording N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate. The 18F-labeled butyrate showed the required properties for in vivo BChE measurement, that is, the lipophilic nature of the authentic ester, high specificity to BChE, a moderate hydrolysis rate, and the hydrophilic nature of the metabolite.

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