7009-13-4Relevant academic research and scientific papers
A simple synthesis of biaryl phospholipase A2 inhibitors: Probing hydrophobic effects
Springer, Dane M.,Bronson, Joanne J.,Mansuri, Muzammil M.,Nettleton, David O.,Tramposch, Kenneth M.
, p. 2669 - 2672 (1996)
A series of biaryl acids has been synthesized by treating diphenic anhydride with a variety of amines. The one step strategy allows the rapid interchange of groups for evaluating the hydrophobic constraints of inhibitors of phopholipase A2. The most active inhibitor synthesized displayed an IC50 = 6 μM against human platelet phospholipase A2.
