Bioorganic and Medicinal Chemistry Letters p. 2669 - 2672 (1996)
Update date:2022-07-30
Topics:
Springer, Dane M.
Bronson, Joanne J.
Mansuri, Muzammil M.
Nettleton, David O.
Tramposch, Kenneth M.
A series of biaryl acids has been synthesized by treating diphenic anhydride with a variety of amines. The one step strategy allows the rapid interchange of groups for evaluating the hydrophobic constraints of inhibitors of phopholipase A2. The most active inhibitor synthesized displayed an IC50 = 6 μM against human platelet phospholipase A2.
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