701-44-0

Basic information

• Product Name: 1-methyl-6-oxo-pyridine-3-carboxamide
• Synonyms: 1-methyl-6-oxo-pyridine-3-carboxamide;N1-Methyl-2-pyridone-5-carboxamide;N'-methyl-2-pyridone-5-carboxamide;3-Pyridinecarboxamide, 1,6-dihydro-1-methyl-6-oxo-;1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxamide;1-Methyl 6-oxo-1,6-dihydro-3-pyridinecarboxamide;1-Methyl-6-oxo-1,6-dihydronicotinamide;2-Py
• CAS NO: 701-44-0
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.1506
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 701-44-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 202-207°C (dec.)
• Boiling Point: 396.7 °C at 760 mmHg
• Flash Point: 193.7 °C
• Appearance: /
• Density: 1.3 g/cm³
• Vapor Pressure: 1.68E-06mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 14.46±0.20(Predicted)
• CAS DataBase Reference: 1-methyl-6-oxo-pyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-6-oxo-pyridine-3-carboxamide(701-44-0)
• EPA Substance Registry System: 1-methyl-6-oxo-pyridine-3-carboxamide(701-44-0)

Safety Data

• Hazardous Substances Data: 701-44-0(Hazardous Substances Data)

Usage

Description

Nudifloramide, known more commonly as N-methyl-2-pyridone-5-carboxamide (2-Py), is a metabolite of niacin via nicotinamide. It can be measured in serum and urine as part of metabolomic studies of niacin or nicotinamide intake and usage. Circulating levels of nudifloramide can be elevated and associated with toxic effects in patients receiving supplemental nicotinamide.

Chemical Properties

Light Brown Solid

Uses

Different sources of media describe the Uses of 701-44-0 differently. You can refer to the following data:
1. Nudifloramide is
2. A metabolite of Niacin
3. Nudifloramide is a metabolite of Niacin (or Nicorinic acid).

Definition

ChEBI: A pyridone that is 2-pyridone substituted with a carboxamide group at C-5 and a methyl group at N-1.

InChI:InChI=1/C7H8N2O2/c1-9-4-5(7(8)11)2-3-6(9)10/h2-4H,1H3,(H2,8,11)

Upstream product

• 10561-91-8 ethyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 
• 6456-44-6 N-methylnicotineamide iodide 
• 3106-60-3 N-methyl-3-carboxamidepyridinium 
• 77837-12-8 1,6-dihydro-6-imino-1-methyl-3-pyridinecarboxamide 
• 107971-06-2 3-aminocarbonyl-1,6-dimethylpyridinium iodide 
• 1005-24-9 1-methylnicotinamide chloride 
• 3719-45-7 1-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid 

Relevant articles and documents

Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase

Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by ～80% at 2 h when dosed in mice orally at 50 mg/kg.

HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS

The present invention is directed to heterocyclic compounds which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical composi

IMINATION OF PYRIDINIUM AND QUINOLINIUM SALTS

A new method for imination of N-alkyl pyridinium- and quinolinium salts is described.It involves a low temperature oxidation of a solution of appropriate substrates in liquid ammonia with potassium permanganate.