10561-91-8

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester is used as an intermediate in the synthesis of various drugs, particularly calcium channel blockers and other cardiovascular medications. Its role in the production of these medications is crucial due to its ability to contribute to the development of compounds that help regulate blood pressure and improve heart function.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester is a key ingredient in the production of pesticides and herbicides. Its incorporation into these products aids in the control of pests and unwanted plant growth, thereby supporting agricultural productivity and crop protection.
Safety Considerations:
Given its flammable nature and potential toxicity, 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester should be handled with caution. Proper safety measures and environmental precautions must be taken to mitigate any hazards associated with its use, storage, and disposal.

InChI:InChI=1/C9H11NO3/c1-3-13-9(12)7-4-5-8(11)10(2)6-7/h4-6H,3H2,1-2H3

Upstream product

• 74925-37-4 ethyl 2-methoxypyridine-5-carboxylate 
• 74357-22-5 methyl-6-ethoxynicotinate 
• 74-89-5 methylamine 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 10129-58-5 3-(ethoxycarbonyl)-1-methylpyridin-1-ium iodide 
• 66171-50-4 methyl 6-hydroxynicotinate 
• 18617-50-0 ethyl 6-hydroxypyridine-3-carboxylate 
• 74-88-4 methyl iodide 
• 3719-45-7 1-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid 

Downstream Products

• 701-44-0 1-methyl-2-pyridone-5-carboxamide 

Relevant academic research and scientific papers

Carbene-catalyzed aerobic oxidation of isoquinolinium salts: Efficient synthesis of isoquinolinones

A mild and environmentally friendly carbene-catalyzed aerobic oxidation of isoquinolinium salts was successfully realized. Accordingly, a diverse set of isoquinolinones and phenanthridinones was efficiently prepared in good to excellent yields. The mechanistic study indicates that the formation of an aza-Breslow intermediate is the crucial step in this transformation. This reaction features ambient air as the sole oxidant and oxygen source, a broad substrate scope, and excellent functional-group tolerance and proceeds under mild reaction conditions. Furthermore, a highly efficient synthesis of bioactive molecules and natural products including N-methylcrinasiadine, N-isopentylcrinasiadine, N-phenethylcrinasiadine, isoindolo[2,1-b]isoquinolin-5(7H)-one, PJ-34, rac-Gusanlung D, rosettacin, 8-oxopseudopalmatine and ilicifoline B was accomplished.

Visible-Light-Mediated Aerobic Oxidation of N-Alkylpyridinium Salts under Organic Photocatalysis

Quinolones and isoquinolones exhibit diverse biological and pharmaceutical activities, and their synthesis is highly desirable under mild conditions. Here, a highly efficient and environmentally friendly visible light-mediated aerobic oxidation of readily available N-alkylpyridinium salts has been developed with Eosin Y as the organic photocatalyst and air as the terminal oxidant, and the reaction provided quinolones and isoquinolones in good yields. The method shows numerous advantages including mild and environmentally friendly conditions, high efficiency, tolerance of wide functional groups and low cost. Furthermore, 4-desoxylonimide with important pharmaceutical activities was effectively prepared by using our method. Therefore, the present method should provide a novel and useful strategy for synthesis and modification of N-heterocycles.

On the Reaction of Some 2H-Pyran-2-one Derivatives with Primary Amines

The versatile reactivity of 6-unsubstituted 2H-pyran-2-ones towards aliphatic and aromatic amines has been studied.It was found that the result of the reaction depends not only on the substitution of 2H-pyran-2-ones and on the structure of amines, but also on the stoichiometric ratio of reacting compounds.