70110-32-6Relevant academic research and scientific papers
Bi(OTf)3-catalyzed three-component synthesis of amidomethylarenes and -heteroarenes
Schneider, Angelika E.,Manolikakes, Georg
, p. 2057 - 2060 (2013)
A highly efficient Bi(OTf)3-catalyzed multicomponent synthesis of amidomethylated arenes and heteroarenes from readily available starting materials has been developed. This reaction proceeds under mild conditions, has a broad substrate scope, and in addition water is generated as only side product. Georg Thieme Verlag Stuttgart, New York.
Bi(OTf)3-Catalyzed Multicomponent α-Amidoalkylation Reactions
Schneider, Angelika E.,Manolikakes, Georg
, p. 6193 - 6212 (2015/06/30)
A bismuth(III) triflate catalyzed three-component synthesis of α-substituted amides starting from amides, aldehydes, and (hetero)arenes is reported. The reaction has a broad substrate scope, encompassing formaldehyde as well as aryl and alkyl aldehydes. Low catalyst loadings are required, and water is formed as the only side product. The scope and limitation of this method will be discussed.
