70112-21-9

Basic information

• Product Name: Benzamide, 5-chloro-2-hydroxy-N,N-dimethyl-
• CAS NO: 70112-21-9
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.637
• Mol File: 70112-21-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzamide, 5-chloro-2-hydroxy-N,N-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 5-chloro-2-hydroxy-N,N-dimethyl-(70112-21-9)
• EPA Substance Registry System: Benzamide, 5-chloro-2-hydroxy-N,N-dimethyl-(70112-21-9)

Safety Data

• Hazardous Substances Data: 70112-21-9(Hazardous Substances Data)

Upstream product

• 618-46-2 m-Chlorobenzoyl chloride 
• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 
• 124-40-3 dimethyl amine 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 

Downstream Products

• 54828-00-1 4-chloro-2-(dimethylaminomethyl)phenol 
• 292636-64-7 C₉H₉ClN₂O₄ 

Relevant articles and documents

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.

BENZIMIDAZOLE COMPOUNDS

There is provided a compound of the formula (1) wherein R1 is an optionally substituted C1-10 alkyl; R2 is H, or a C1-6 alkyl which may be substituted with 1 to 3 substituents; R3 is a 5- or 6-membered aromatic group which may be substituted with 1 to 5 substituents, wherein the 5- or 6-membered aromatic group may be fused with a 5- or 6- membered ring which may be substituted with 1 to 3 C1-6 alkyls; R4 is a hydrogen, a halogen, a hydroxy, a cyano, a C1-6 alkyl or a C1-6 alkoxy; Z is -O-, -S-, -SO-, -SO2-, or - NR5- wherein R5 is a hydrogen or a C1-6 alkyl; or a salt thereof or a prodrug thereof, which have CRF receptor antagonist activity and use thereof.

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.