701209-15-6

Basic information

• Product Name: (4S,5S)-5-[(1-benzyl-5,5-dimethyl-3-oxo-2-pyrazolidinyl)carbonyl]-4-methyl-3-tert-butyl-4,5-dihydroisoxazole
• Synonyms: (4S,5S)-5-[(1-benzyl-5,5-dimethyl-3-oxo-2-pyrazolidinyl)carbonyl]-4-methyl-3-tert-butyl-4,5-dihydroisoxazole
• CAS NO: 701209-15-6
• Molecular Weight: 371.48
• Mol File: 701209-15-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4S,5S)-5-[(1-benzyl-5,5-dimethyl-3-oxo-2-pyrazolidinyl)carbonyl]-4-methyl-3-tert-butyl-4,5-dihydroisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5S)-5-[(1-benzyl-5,5-dimethyl-3-oxo-2-pyrazolidinyl)carbonyl]-4-methyl-3-tert-butyl-4,5-dihydroisoxazole(701209-15-6)
• EPA Substance Registry System: (4S,5S)-5-[(1-benzyl-5,5-dimethyl-3-oxo-2-pyrazolidinyl)carbonyl]-4-methyl-3-tert-butyl-4,5-dihydroisoxazole(701209-15-6)

Safety Data

• Hazardous Substances Data: 701209-15-6(Hazardous Substances Data)

Upstream product

• 1092570-21-2 1-benzyl-2-crotonoyl-5,5-dimethyl-3-pyrazolidinone 
• 3273-26-5 1-chloro-2,2-dimethyl-propan-1-one oxime 
• 131391-08-7 1-benzyl-5,5-dimethyl-pyrazolidin-3-one 
• 365456-25-3 1-benzyl-2-[(E)-2-butenoyl]-5,5-dimethyl-pyrazolidin-3-one 
• 27143-81-3 tert-butyl nitrile oxide 
• 42953-82-2 5,5-dimethylpyrazolidin-3-one 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Asymmetric 1,3-dipolar cycloaddition reactions of nitrile oxides catalyzed by chiral binaphthyldiimine-Ni(II) complexes

Asymmetric cycloaddition reactions between several nitrile oxides and 3-(2-alkenoyl)-2-oxazolidinones and 2-(2-alkenoyl)-3-pyrazolidinone derivatives were carried out in the presence of chiral binaphthyldiimine (BINIM)-Ni(II) complexes as catalysts. Using (tf)-BENM-4(3,5-xylyl)-2QN-Ni(II) complex (30 mol %), good regioselectivity (4-Me/5-Me = 85:15) along with high enantioselectivity (96% ee) of the 4-Me adduct were obtained for the reaction between isolable 2,4,6-trimethylbenzonitrile oxide and 3-crotonoyl-5,5-dimethyl-2-oxazolidinone. Substituted and unsubstituted benzonitrile oxides and aliphatic nitrile oxides, which were generated from the corresponding hydroximoyl chloride in the presence of MS 4A, were reacted with 3-crotonoyl-5,5-dimethyl-2-oxazolidinone, 5,5-dimethyl-3-(2-pentenoyl)-2-oxazolidinone, 5,5-dimethy-3-[3-(ethoxycarbonyl) propenoyl]-2-oxazolidinone, 1-benzyl-2-crotonoyl-5,5-dimethyl-3-pyrazolidinone, and 1-ben-zyl-2-[3-(ethoxycarbonyl)propenoyl]-5,5-dimethy-3-pyrazolidinone in the presence of (K)-BENM-4Ph-2QN-Ni(II) or (tf)-BENM-4(3,5-xylyl)-2QN-Ni(II) complexes (10-30 mol %) as catalysts to give the corresponding cycloadducts in high yields, with high regioselectively (4-R/5-R = 85:15-99:1) and with moderate to high enantioselectivities (42-95% ee) of the 4-R adducts. Higher enantioselectivities and regioselectivities were obtained for the reactions using pyrazolidinone derivatives as the dipolarophiles. For the cycloadditions of 2-(2-alkenoyl)-1-benzyl-5,5-dimethyl-3-pyrazolidinones catalyzed by (tf)-BENM-4(3,5-xylyl)-2QN-Ni(II) complex (30 mol %), the enantioselectivity varied from 75% to 95% ee. The reactions between several nitrile oxides and 2-acryloyl-1-benzyl-5,5-dimethyl-3-pyrazolidinone in the presence of (R)-BINIM-4(3,5-xylyl)-2QN-Ni(II) complex (10 mol %) resulted in enantioselectivities (79-91% ee) that exceed those of previously reported enantioselective cycloadditions of acrylic acid derivatives. Furthermore, studies using a molecular modeling program using PM3 calculations were carried out to gain insight into the mechanisms of the asymmetric induction. 2009 American Chemical Society.