701244-26-0Relevant articles and documents
Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors
Pecchi, Sabina,Renhowe, Paul A.,Taylor, Clarke,Kaufman, Susan,Merritt, Hanne,Wiesmann, Marion,Shoemaker, Kevin R.,Knapp, Mark S.,Ornelas, Elizabeth,Hendrickson, Thomas F.,Fantl, Wendy,Voliva, Charles F.
supporting information; experimental part, p. 6895 - 6898 (2011/02/26)
PI3 Kinases are a family of lipid kinases mediating numerous cell processes such as proliferation, migration, and differentiation. The PI3 kinase pathway is often de-regulated in cancer through PI3Kα overexpression, gene amplification, mutations, and PTEN