70152-88-4Relevant academic research and scientific papers
Trimethylsilyl Esters as Novel Dual-Purpose Protecting Reagents
Chen, Jyun-Siao,Huang, Po-Hsun,Hsieh, Ya-Chi,Liu, Jen-Wei,Hsu, Hsiao-Lin,Zhang, Kai-Min,Wu, Ren-Tsung,Chang, Ting-Shuo,Liu, Yu-Hao,Wu, Hsin-Ru,Luo, Shun-Yuan
supporting information, p. 754 - 762 (2021/12/02)
Trimethylsilyl esters, AcOTMS, BzOTMS, TCAOTMS, etc., are inexpensive and chemically stable reagents that pose a negligible environmental hazard. Such compounds prove to serve as efficient dualpurpose reagents to respectively achieve acylation and trimethylsilylation of alcohols under acidic or basic conditions. Herein, a detailed study on protection of various substrates and new methodological investigations is described.
Preparation method of 3-amino-4-chlorobenzoic acid hexadecyl ester
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Paragraph 0037; 0041; 0045; 0049, (2021/01/28)
The invention provides a preparation method of 3-amino-4-chlorobenzoic acid hexadecyl ester. The preparation method comprises the following steps: by taking p-chlorobenzoic acid as an initial raw material, firstly carrying out acylating chlorination reaction on p-chlorobenzoic acid, DMF (Dimethyl Formamide) and a chlorination reagent to generate p-chlorobenzoyl chloride; then carrying out esterification reaction with hexadecanol to generate hexadecyl p-chlorobenzoate; then carrying out nitration reaction with sulfuric acid and nitric acid to generate 3-nitro-4-chlorobenzoic acid hexadecyl ester; and finally, carrying out a reduction reaction with hydrogen under the catalysis of raney nickel to generate the 3-amino-4-chlorobenzoic acid hexadecyl ester. The preparation method disclosed by the invention is high in yield, high in product purity and low in cost.
