70155-33-8Relevant academic research and scientific papers
The First Racemic Total Syntheses of the Antiplasmodials Watsonianones A and B and Corymbone B
Zhang, Xiao,Wu, Guiyun,Huo, Luqiong,Guo, Xueying,Qiu, Shengxiang,Liu, Hongxin,Tan, Haibo,Hu, Yingjie
supporting information, p. 3 - 7 (2019/11/21)
The first biomimetic total syntheses of three biologically meaningful acylphloroglucinols, watsonianones A and B and corymbone B, with potent antiplasmodial activity, were performed. Their total syntheses were carried out through a diversity-oriented synthetic strategy from congener 2,2,4,4-tetramethyl-6-(3-methylbutylidene)cyclohexane-1,3,5-trione with high step efficiency. The spontaneous enolization/air oxidation of the precursor 2,2,4,4-tetramethyl-6-(3-methylbutylidene)cyclohexane-1,3,5-trione through a singlet O2-induced Diels-Alder reaction pathway to assemble the key biosynthetic peroxide intermediate is also discussed.
Hydrogen-bonded rotamers of 2′,4′,6′-trihydroxy-3′-formyldihydrochalcone, an intermediate in the synthesis of a dihydrochalcone from Leptospermum recurvum
Mustafa, Kamarul'Ain,Kjaergaard, Henrik G.,Perry, Nigel B.,Weavers, Rex T.
, p. 6113 - 6120 (2007/10/03)
Synthesis of 2′,4′,6′-trihydroxy-3′-methyldihydrochalcone, isolated as a natural product for the first time (ex Leptospermum recurvum), proceeds through 2′,4′,6′-trihydroxy-3′-formyldihydrochalcone. Two stable rotamers of this formyl derivative have been
