70155-33-8Relevant articles and documents
The First Racemic Total Syntheses of the Antiplasmodials Watsonianones A and B and Corymbone B
Zhang, Xiao,Wu, Guiyun,Huo, Luqiong,Guo, Xueying,Qiu, Shengxiang,Liu, Hongxin,Tan, Haibo,Hu, Yingjie
, p. 3 - 7 (2019/11/21)
The first biomimetic total syntheses of three biologically meaningful acylphloroglucinols, watsonianones A and B and corymbone B, with potent antiplasmodial activity, were performed. Their total syntheses were carried out through a diversity-oriented synthetic strategy from congener 2,2,4,4-tetramethyl-6-(3-methylbutylidene)cyclohexane-1,3,5-trione with high step efficiency. The spontaneous enolization/air oxidation of the precursor 2,2,4,4-tetramethyl-6-(3-methylbutylidene)cyclohexane-1,3,5-trione through a singlet O2-induced Diels-Alder reaction pathway to assemble the key biosynthetic peroxide intermediate is also discussed.
Syntheses of 2,4,6-trihydroxy-, 2,4,6-trihydroxy-5-methyl- and 2,4,5,6-tetrahydroxy-substituted 3-(3-phenylpropionyl)benz-aldehydes and their bactericidal activity
Sato,Obara,Takeuchi,Tawaraya,Endo,Onodera
, p. 491 - 493 (2007/10/02)
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