7019-19-4

Basic information

• Product Name: 1-Hydroxy-2-octanone
• Synonyms: 1-Hydroxy-2-octanone
• CAS NO: 7019-19-4
• Molecular Formula: C₈H₁₆O₂
• Molecular Weight: 144.21144
• Mol File: 7019-19-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 189.7℃ at 102kPa
• Appearance: /
• Density: 932 at 20℃
• Vapor Pressure: 27Pa at 20℃
• CAS DataBase Reference: 1-Hydroxy-2-octanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hydroxy-2-octanone(7019-19-4)
• EPA Substance Registry System: 1-Hydroxy-2-octanone(7019-19-4)

Safety Data

• Hazardous Substances Data: 7019-19-4(Hazardous Substances Data)

Usage

General Description

1-Hydroxy-2-octanone, also known as 2-Octanone-1-ol, is a chemical compound with the molecular formula C8H16O2. It is a colorless liquid with a characteristic fruity odor and is commonly used as a flavoring agent in the food and beverage industry. 1-Hydroxy-2-octanone is also utilized as a solvent in the production of perfumes and other aromatic products. It can be prepared by the oxidation of 2-Octanol or by the reduction of 2-Octanone. Additionally, 1-Hydroxy-2-octanone has potential applications in the pharmaceutical and cosmetic industries due to its unique chemical properties.

Upstream product

• 629-05-0 n-octyne 
• 111-66-0 oct-1-ene 
• 1117-86-8 1,2-octandiol 
• 71985-43-8 1-[(trimethylsilyl)oxy]-1-octene 
• 77149-60-1 1-ethoxy-1-octene 
• 64-17-5 ethanol 
• 67-56-1 methanol 
• 111-13-7 hexyl-methyl-ketone 

Downstream Products

• 80506-37-2 2,4,6-Trimethyl-benzenesulfonic acid 2-oxo-octyl ester 
• 1429471-00-0 benzyl (5S)-5-[(1R,2R)-1,2-dihydroxy-3-oxononyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 1429471-01-1 benzyl (5S)-5-[(1S,2S)-1,2-dihydroxy-3-oxononyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 1613415-73-8 (R)-4-hexyl-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide 
• 63988-10-3 1-chloro-2-octanone 
• 1025506-10-8 4-hexyl-5H-[1,2,3]oxathiazole 2,2-dioxide 
• 111-14-8 oenanthic acid 
• 80520-06-5 1-<<(4-Methylphenyl)sulfonyl>oxy>-2-octanon 
• 80519-98-8 1-benzenesulfonyloxy-2-octanone 

Relevant articles and documents

A Two-Step Oxidative Cleavage of 1,2-Diol Fatty Esters into Acids or Nitriles by a Dehydrogenation–Oxidative Cleavage Sequence

Dehydrogenative oxidation of vicinal alcohols catalyzed by a commercially 64 wt.% Ni/SiO2 catalyst leads to the formation of α-hydroxyketone. This first step was developed without additional solvent according to two protocols: “under vacuum” or “with an olefin scavenger”. The synthesis of ketols was carried out with good conversions and selectivities. The recyclability of the supported nickel was also studied. Acyloin was then cleaved with oxidative reagent “formic acid/hydrogen peroxide”, which is cheap and can be used on a large scale for industrial oxidation processes. The global yield of this sequential system was up to 80 % to pelargonic acid and azelaic acid monomethyl ester without intermediate purification. By treating the acyloin intermediate with hydroxylamine, nitriles were obtained with a good selectivity.

Manganese catalyzed cis-dihydroxylation of electron deficient alkenes with H2O2

A practical method for the multigram scale selective cis-dihydroxylation of electron deficient alkenes such as diethyl fumarate and N-alkyl and N-aryl-maleimides using H2O2 is described. High turnovers (>1000) can be achieved with this efficient manganese based catalyst system, prepared in situ from a manganese salt, pyridine-2-carboxylic acid, a ketone and a base, under ambient conditions. Under optimized conditions, for diethyl fumarate at least 1000 turnovers could be achieved with only 1.5 equiv. of H2O2 with d/l-diethyl tartrate (cis-diol product) as the sole product. For electron rich alkenes, such as cis-cyclooctene, this catalyst provides for efficient epoxidation.

Efficient oxidation of alcohols to carbonyl compounds with molecular oxygen catalyzed by N-hydroxyphthalimide combined with a Co species

Highly efficient catalytic oxidation of alcohols with molecular oxygen by N-hydroxyphthalimide (NHPI) combined with a Co species was developed. The oxidation of 2-octanol in the presence of catalytic amounts of NHPI and Co(OAc)2 under atmospheric dioxygen in AcOEt at 70 °C gave 2-octanone in 93% yield. The oxidation was significantly enhanced by adding a small amount of benzoic acid to proceed smoothly even at room temperature. Primary alcohols were oxidized by NHPI in the absence of any metal catalyst to form the corresponding carboxylic acids in good yields. In the oxidation of terminal vic-diols such as 1,2-butanediol, carbon-carbon bond cleavage was induced to give one carbon less carboxylic acids such as propionic acid, while internal vic-diols were selectively oxidized to 1,2-diketones.