701910-48-7

Upstream product

• 38487-86-4 2-amino-4-chlorobenzonitrile 
• 133095-91-7 3,4,5-trimethoxyphenylmagnesium bromide 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 

Downstream Products

• 867070-51-7 1-(2-amino-4-chloro-phenyl)-1-(3,4,5-trimethoxy-phenyl)-ethanol 
• 867070-50-6 6-chloro-9-(3,4,5-trimethoxy-phenyl)-3H-furo[3,4-b]quinolin-1-one 

Relevant academic research and scientific papers

Insecticidal heterolignans-Tubuline polymerization inhibitors with activity against chewing pests

Starting from natural product podophyllotoxin 1 substituted heterolignans were identified with promising insecticidal in vivo activity. The impact of substitution in each segment of the core structure was investigated in a detailed SAR study, and variation of substituents in both aromatic moieties afforded derivatives 5 and 43 with broad insecticidal activity against lepidopteran and coleopteran species. In vitro measurements supported by modeling studies indicate that heterolignans 3-134 act as tubuline polymerization inhibitors interacting with the colchicine-binding site. Insect specific structure-activity effects were observed showing that the insecticidal SAR described herein differs from reported cytotoxicity studies.

ANNELATED QUINOLINE DERIVATIVES AS PESTICIDE

The invention relates to the use of quinoline derivatives of formula (I), where the dotted bond is either a single- or double-bond and the substituents have the meaning given in the description, as plant treatment agents, in particular, for the prevention

Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents

A new series of 3-aminobenzophenone compounds as potent inhibitors of tubulin polymerization was discovered based on the mimic of the aminocombretastatin molecular skeleton. Lead compounds 5 and 11, with alkoxy groups at the C-4 position of B-ring, were p