70199-60-9

Basic information

• Product Name: 4-ethoxymethyl-pyridine
• Synonyms: 4-ethoxymethyl-pyridine
• CAS NO: 70199-60-9
• Molecular Formula: C₇H₉NO
• Molecular Weight: 137
• Mol File: 70199-60-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-ethoxymethyl-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethoxymethyl-pyridine(70199-60-9)
• EPA Substance Registry System: 4-ethoxymethyl-pyridine(70199-60-9)

Safety Data

• Hazardous Substances Data: 70199-60-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 108-89-4 picoline 
• 586-95-8 pyridine-4-methanol 
• 1007-48-3 4-acetoxymethylpyridine 
• 74-88-4 methyl iodide 
• 872-85-5 pyridine-4-carbaldehyde 
• 124-41-4 sodium methylate 
• 1822-51-1 4-picolylchloride hydrochloride 

Downstream Products

• 108-89-4 picoline 

Relevant articles and documents

4-methoxymethylpyridine synthesis method

The invention relates to the field of organic chemistry, particularly to a 4-methoxymethylpyridine synthesis method, which comprises: carrying out a bromination reaction on 4-methylpyridine as a raw material to obtain 4-bromo-methylpyridine; carrying out a reaction on the 4-bromo-methylpyridine and trimethylamine to obtain (4-pyridylmethyl)trimethyl ammonium bromide; and dissolving the (4-pyridylmethyl)trimethyl ammonium bromide in methanol, adding sodium methoxide, and carrying out heating reflux for 1 h in the presence of nitrogen to obtain the 4-methoxymethylpyridine. According to the invention, by using the synthesis method, 4-methylpyridine is used as the raw material, and is subjected to the bromination reaction to obtain 4-bromo-methylpyridine, the 4-bromo-methylpyridine reacts withtrimethylamine to obtain (4-pyridylmethyl)trimethyl ammonium bromide, and finally the (4-pyridylmethyl)trimethyl ammonium bromide reacts with sodium methoxide to obtain the 4-methoxymethylpyridine; and the synthesis method is high in total yield, cheap in raw material price, short in reaction time, mild in condition and simple in process operation.

Synthesis of Diarylated 4-Pyridylmethyl Ethers via Palladium-Catalyzed Cross-Coupling Reactions

The direct arylation of weakly acidic sp3-hybridized C–H bonds via deprotonated cross-coupling processes (DCCP) is a challenge. Herein, a palladium(NIXANTPHOS)-based catalyst for the monoarylation of 4-pyridylmethyl 2-aryl ethers to generate di

Synthesis of alkyl heteryl ethers from acetates under interphase catalysis conditions in a liquid/solid system

The reaction of acetates of heterocyclic alcohols with alkyl halides in the two-phase catalytic system of solid KOH/C6H6/18-crown-6 at room temperature leads selectively to the formation of the corresponding heterocyclic ethers in 32-93% yield. 1998 Plenum Publishing Corporation.