70227-88-2

Upstream product

• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 102-54-5 ferrocene 
• 13685-24-0 bis(4-trifluoromethylphenyl)phosphine chloride 
• 402-43-7 p-trifluoromethylphenyl bromide 

Downstream Products

• 79151-85-2 HRh(CO)(1,1'-bis(bis(p-(trifluoromethyl)phenyl)phosphino)ferrocene)(PPh₃) 
• 565441-36-3 Pd(1,1'-bis[di(4-(trifluoromethyl)phenyl)phosphinoferrocene)(C₆H₅)(OC₆H₄-4-OMe) 
• 565441-30-7 (1,1'-bis[di(4-(trifluoromethyl)phenyl)phosphino]ferrocene)Pd(C₆H₄-4-CN)(Br) 
• 475501-82-7 [Pd(η3-deuterio-1,1-dimethylallyl)(1,1'-bis[di(4-trifluoromethylphenyl)phosphino]ferrocene)][B(C6H3-3,5-(CF3)2)4] 
• 653588-00-2 (1,1'-bis(di(4-trifluoromethylphenyl)phosphino)ferrocene)(p-trifluoromethylphenyl)iodopalladium(II) 

Relevant academic research and scientific papers

Cross-Coupling Reactions of Monosubstituted Tetrazines

A Ag-mediated Pd-catalyzed cross-coupling method for 3-bromo-1,2,4,5-tetrazine with boronic acids is presented. Electronic modification of the 1,1′-bis(diphenylphosphine)ferrocene (dppf) ligand was found to be crucial for good turnover. Using this fast method, a variety of alkyl-, heteroatom-, and halide-substituted aryl- and heteroaryl-tetrazines were prepared (29 examples, up to 87% yield).

Rhodium-Catalyzed Cyclization of Terminal and Internal Allenols: An Atom Economic and Highly Stereoselective Access Towards Tetrahydropyrans

A comprehensive study of a diastereoselective Rh-catalyzed cyclization of terminal and internal allenols is reported. The methodology allows the atom economic and highly syn-selective access to synthetically important 2,4-disubstituted and 2,4,6-trisubstituted tetrahydropyrans (THP). Furthermore, its utility and versatility are demonstrated by a great functional-group compatibility and the enantioselective total synthesis of (?)-centrolobine.

Iridium-Catalyzed α-Selective Arylation of Styrenes by Dual C?H Functionalization

An IrI-system modified with a ferrocene derived bisphosphine ligand promotes α-selective arylation of styrenes by dual C?H functionalization. These studies offer a regioisomeric alternative to the Pd-catalyzed Fujiwara–Moritani reaction.

Electronic Effect of Ligands on the Stability of Nickel-Ketene Complexes

Electronically variant (dppf)Ni(ketene) complexes were synthesized and characterized to perform kinetic analysis on their decomposition through a decarbonylation/disproportion process to Ni-CO complexes and alkenes. Ligands containing electron-donating groups stabilized such complexes, whereas an electron-withdrawing group was found to destabilize them. Hammett analysis on the decomposition reaction revealed the buildup of negative charges in the rate-determining step, which corroborates past computational models.