70236-15-6Relevant academic research and scientific papers
Room-Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity
Lau, Kai Kiat,Liao, Gang,Ng, Teng Wei,Pan, Hui-Jie,Zhao, Yu
supporting information, p. 11384 - 11389 (2020/06/02)
We report herein an unprecedented highly efficient Guerbet-type reaction at room temperature (catalytic TON up to >6000). This β-alkylation of secondary methyl carbinols with primary alcohols has significant advantage of delivering higher-order secondary alcohols in an economical, redox-neutral fashion. In addition, the first enantioselective Guerbet reaction has also been achieved using a commercially available chiral ruthenium complex to deliver secondary alcohols with moderate yield and up to 92 % ee. In both reactions, the use of a traceless ketone promoter proved to be beneficial for the catalytic efficiency.
Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts
Zhong, Cheng,Wang, Yikai,Hung, Alvin W.,Schreiber, Stuart L.,Young, Damian W.
supporting information; experimental part, p. 5556 - 5559 (2011/12/05)
An intramolecular aza-Michael reaction with a Cbz carbamate and an enone is reported to result in 3,5-disubstituted nitrogen-containing heterocycles. Either cis or trans isomers were obtained selectively using chiral substrates and an achiral Pd (II) comp
