70243-92-4Relevant academic research and scientific papers
Sequential Cu-catalyzed amidation-base-mediated camps cyclization: A two-step synthesis of 2-aryl-4-quinolones from o-halophenones
Jones, Carrie P.,Anderson, Kevin W.,Buchwald, Stephen L.
, p. 7968 - 7973 (2007)
(Chemical Equation Presented) A direct two-step method for the preparation of 2-aryl- and 2-vinyl-4-quinolones that utilizes a copper-catalyzed amidation of o-halophenones followed by a base-promoted Camps cyclization of the resulting N-(2-ketoaryl)amides is described. With CuI, a diamine ligand, and base as the catalyst system, the amidation reactions proceed in good yields for a range of aryl, heteroaryl, and vinyl amides. The subsequent Camps cyclization efficiently provides the desired 4-quinolones with the conditions that are described.
A NEW APPROACH TO THE BICYCLIC HYDROXYLAMINE HEMIKETAL RING SYSTEM OF ANTITUMOUR-ANTIBIOTIC FR900482 VIA OXIDATIVE RING EXPANSION OF A TETRAHYDROPPYRROLOINDOLE
Dimitrienko, Gary I.,Denhart, Derek,Mithani, Salim,Prasad, Ganesh K. B.,Taylor, Nicholas J.
, p. 5705 - 5708 (1992)
The bicyclic hydroxylamine hemiketal ring system found in antitumour antibiotic FR900482 can be produced via an oxidative ring expansion of the 9a-hydroxy-2,3,9,9a-tetrahydro-1H-pyrroloindole ring system by reaction with Davis' reagent.
Intramolecular Keto Lactam Condensation: A Convenient and Straightforward Approach to Bicyclic Vinylogous Lactams
Huang, Pei-Qiang,Fan, Ting
supporting information, p. 6369 - 6374 (2017/10/24)
Although the aldol condensation is a well-known reaction, the aza-type aldol condensation, namely, the intramolecular condensation of common keto lactams leading to bicyclic vinylogous lactams, is a highly demanding transformation, with potential applicat
A mild, one-pot synthesis of 4-quinolones via sequential Pd-catalyzed amidation and base-promoted cyclization
Huang, Jinkun,Chen, Ying,King, Anthony O.,Dilmeghani, Mina,Larsen, Robert D.,Faul, Margaret M.
supporting information; experimental part, p. 2609 - 2612 (2009/05/27)
(Chemical Equation Presented) A mild, one-pot synthesis of 4-quinolones is described. Under the optimal conditions, a variety of 2-substituted 4-quinolones were synthesized via sequential palladium-catalyzed amidation of 2′-bromoacetophenones followed by base-promoted intramolecular cyclization.
