70244-88-1

Basic information

• Product Name: 1,3-Butanedione, 1-phenyl-2-(2-propynyl)-
• CAS NO: 70244-88-1
• Molecular Formula: C13H12O2
• Molecular Weight: 200.237
• Mol File: 70244-88-1.mol

Chemical Properties

• CAS DataBase Reference: 1,3-Butanedione, 1-phenyl-2-(2-propynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Butanedione, 1-phenyl-2-(2-propynyl)-(70244-88-1)
• EPA Substance Registry System: 1,3-Butanedione, 1-phenyl-2-(2-propynyl)-(70244-88-1)

Safety Data

• Hazardous Substances Data: 70244-88-1(Hazardous Substances Data)

Upstream product

• 106-96-7 propargyl bromide 
• 93-91-4 1-phenylbutan-1,3-dione 

Downstream Products

• 74971-22-5 2-Methyl-1-phenyl-2-prop-2-ynyl-butane-1,3-dione 
• 43020-09-3 1-(5-methyl-2-phenylfuran-3-yl)ethan-1-one 
• 66685-28-7 (2,5-dimethylfuran-3-yl)(phenyl)methanone 
• 146896-49-3 3-benzoyl-4,5-dihydro-2-methyl-5-methylenefuran 
• 1240615-68-2 (1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)(phenyl)methanone 
• 74971-28-1 endo-7,8-diaza-1,9-dimethyl-6-phenyl-9-propargyltricyclo<4.2.1.0^2,5>nona-3,7-diene 
• 74979-22-9 3,4-dimethyl-5-phenyl-4-propargylisopyrazole 

Relevant articles and documents

Rate Enhancement in CAN-Promoted Pd(PPh3)2Cl2-Catalyzed Oxidative Cyclization: Synthesis of 2-Ketofuran-4-carboxylate Esters

Stoichiometric ceric ammonium nitrate (CAN) and a catalytic amount of Pd(PPh3)2Cl2 (5 mol %) can rapidly produce multisubstituted 2-ketofuran-4-carboxylate esters from 2-propargylic 1,3-ketoesters via oxidative O-cyclization reaction. Pd(PPh3)2Cl2 was found to be the crucial catalyst as its inclusion greatly enhanced the rate of the reaction and cleanly afforded the products within minutes. Over 30 substrates were successfully converted to the desired compounds in mostly moderate to good yields.

Bi(OTf)3-mediated cycloisomerization of γ-alkynyl arylketones: Application to the synthesis of substituted furans

A novel Bi(OTf)3-mediated cycloisomerization of γ-alkynyl arylketones 4, 7, or 10 with molecular sieve (MS) in MeNO2 affords 3-substituted furans 3, 8, or 11 at rt for 3 h in moderate to good yields. The method provides mild, less-to

Gold-Catalyzed Sequential Amination/Annulation Reactions of 2-Propynyl-1,3-dicarbonyl Compounds

The gold(III)-catalyzed sequential amination/annulation reaction of 2-propynyl-1,3-dicarbonyl compounds 1 with primary amines 2 produces 1,2,3,5-substituted pyrroles 4 in moderate to high yields.

Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: Lead identification and SAR of 3- and 4-substituted derivatives

Through computationally directed broad screening, a novel 1,5- diphenylpyrazole (DPP) class of HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) has been discovered. Compound 2 (PNU-32945) was found to have good activity versus wild-type (ICs

Sequential alkylation/transition metal catalysed annulation reactions of 1,3-dicarbonyl compounds with propargyl bromide

β-Diketones, β-ketoesters and βketonitriles in the presence of propargyl bromide, DBU and a catalytic amount of CuI in toluene give 2,3,5-trisubstituted furans through sequential alkylation/cyclisation/isomerisation reactions. (C) 2000 Elsevier Science Ltd.

Regio- and Stereoselective 1,2 Wagner-Meerwein Shifts during Trifluoroacetic Acid Catalyzed Isomerization of Unsymmetrically Substituted Tricyclo2,4>heptanes

The regioselectivity and stereoselectivity which materialize upon trifluoroacetic acid promoted isomerization of variously substituted tricyclo2,4>heptanes have been experimentally determined.The highly strained hydrocarbon substrates h