66685-28-7

Upstream product

• 625-86-5 2,5-dimethylfuran 
• 93-97-0 benzoic acid anhydride 
• 146896-49-3 3-benzoyl-4,5-dihydro-2-methyl-5-methylenefuran 
• 106-96-7 propargyl bromide 
• 93-91-4 1-phenylbutan-1,3-dione 
• 70244-88-1 1-phenyl-2-(prop-2-ynyl)butane-1,3-dione 
• 98-88-4 benzoyl chloride 
• 81396-46-5 3-benzoylhexane-2,5-dione 
• 146896-37-9 (2-methyl-5-((phenylselanyl)methyl)-4,5-dihydrofuran-3-yl)(phenyl)methanone 
• 10225-38-4 1-phenyl-2-(2-propenyl)-1,3-butanedione 
• 2227-79-4 benzenecarbothioamide 
• 93-58-3 benzoic acid methyl ester 
• 36967-85-8 benzoyl triflate 
• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Photocatalytic synthesis of tetra-substituted furans promoted by carbon dioxide

We report a simple protocol for the transition metal-free, visible-light-driven conversion of 1,3-diketones to tetra-substituted furan skeleton compounds in carbon dioxide (CO2) atmosphere under mild conditions. It was found that CO2could be incorporated at the diketone enolic OH position, which was key to enabling the cleavage of a C-O bond during the rearrangement of a cyclopropane intermediate. This method allows for the same-pot construction of two isomers of the high-value tetra-substituted furan scaffold. The synthetic scope and preliminary mechanistic investigations are presented.

Decarboxylation with Carbon Monoxide: The Direct Conversion of Carboxylic Acids into Potent Acid Triflate Electrophiles

We report a new strategy for the conversion of carboxylic acids into potent acid triflate electrophiles. The reaction involves oxidative carbonylation of carboxylic acids with I2 in the presence of AgOTf, and is postulated to proceed via acyl hypoiodites that react with CO to form acid triflates. Coupling this chemistry with subsequent trapping with arenes offers a mild, room temperature approach to generate ketones directly from broadly available carboxylic acids without the use of corrosive and reactive Lewis or Bronsted acid additives, and instead from compounds that are readily available, stable, and functional group compatible.

Hybrid tetra-aryl ethylene compound, polymer and preparation method and application thereof

The invention discloses a hybrid tetra-aryl ethylene compound. The structure of the hybrid tetra-aryl ethylene compound is as shown in the specification, wherein, Ar1 is phenyl or hexahydric heteroaryl; Ar2 and Ar3 are phenyl, hexahydric heteroaryl or quinary heteroaryl independently and respectively; X is nitrogen, oxygen, sulphur or silicon; R1, R2 and R3 are hydrogen, fluorine, chorine, bromine, iodine, methyl, ethyl, propyl, isopropyl, normal-butyl, isobutyl, tertiary butyl, methoxy, ethyoxyl, amino, hydroxyl, carboxyl, nitryl, sulfonic acid group, trifluoromethyl, phenyl, benzyl, benzoyl, para-bromophenyl, para-fluorophenyl, thiophene, pyridine, or crown ether. The invention further discloses a preparation method of the hybrid tetra-aryl ethylene compound and an application thereof, and discloses a polymer of the hybrid tetra-aryl ethylene compound, a preparation method and an application thereof. The hybrid tetra-aryl ethylene compound is unique in structure performance; the compound has good photochromic performance as well as excellent aggregation-induced emission performance.

Method for preparing poly-substituted furan compound by condensing tricarbonyl compound under effect of titanium tetrachloride

The invention provides a method for preparing a poly-substituted furan compound by condensing a tricarbonyl compound under an effect of titanium tetrachloride. The method comprises the following steps: by taking methylene dichloride or methylbenzene as a solvent, causing the tricarbonyl compound react with titanium tetrachloride while stirring under inert gas shielding, ending the reaction and then separating, thereby acquiring the poly-substituted furan compound. The compounding method provided by the invention has the characteristics of easily acquired raw materials, low cost, mild reaction condition, simple and easily controlled operation, less side reaction, simple post-processing, higher product yield, capability of greatly saving production cost, higher economic benefit and suitability for industrial mass production.

Bi(OTf)3-mediated cycloisomerization of γ-alkynyl arylketones: Application to the synthesis of substituted furans

A novel Bi(OTf)3-mediated cycloisomerization of γ-alkynyl arylketones 4, 7, or 10 with molecular sieve (MS) in MeNO2 affords 3-substituted furans 3, 8, or 11 at rt for 3 h in moderate to good yields. The method provides mild, less-to

W(CO)5(L)-catalyzed cyclization of α-alkynyl-β- dicarbonyl derivatives: Synthesis of methylenelactones, furans, and methylenecyclopentanes

W(CO)5(L)-Catalyzed cyclization of α-alkynyl-β-keto acids, keto esters, and diketones provides methylenelactones, furans, and methylenecyclopentanes via 5-exo-dig cyclization. Also, the present approach can be further applied to 5-endo-dig cycl

Palladium-Catalyzed Oxidative Alkoxylation of α-Alkenyl β-Diketones to Form Functionalized Furans

Treatment of 4-allyl-2,6-dimethyl-3,5-heptanedione with a catalytic amount of PdCl2(CH3CN)2 (5 mol %) and a stoichiometric amount of CuCl2 (2.2 equiv) in dioxane at 60 °C for 12 h formed 3-isobutyryl-2-isopropyl-5-methylfuran in 77% isolated yield. A number of α-alkenyl β-dike-tones underwent oxidative alkoxylation under these conditions to form 2,3,5-trisubsituted furans in moderate to good yield.

Sequential alkylation/transition metal catalysed annulation reactions of 1,3-dicarbonyl compounds with propargyl bromide

β-Diketones, β-ketoesters and βketonitriles in the presence of propargyl bromide, DBU and a catalytic amount of CuI in toluene give 2,3,5-trisubstituted furans through sequential alkylation/cyclisation/isomerisation reactions. (C) 2000 Elsevier Science Ltd.

Elimination Reactions of Terminal β-Oxy Selenoxides. Synthesis of Aryl and Vinyl Enol Ethers and of Furans, Oxazoles, and Thiazoles

Elimination reactions of terminal selenoxides holding an alkoxy group in the β-position, RCH(OR)CH2SeOPh, are usually difficult and can give rise to complex reaction mixtures.We report that these reactions take place more easily whenever the oxygen atom is linked to an unsaturated group (-CH=CHR, -Ar, -CR=O, -CH=NR).These selenoxides are easily available, and the elimination reaction was employed to effect useful syntheses of both open-chain and cyclic aryl and vinyl enol ethers.Moreover, by simple isomerization with acids or bases the cyclic derivatives can be transformed into the corresponding furans.The same procedure has been employed to synthesize substituted oxazoles and thiazoles also.

Photoreaction of arenecarbothioamides with 5-membered heteroaromatics. The regioselective photoinduced aroylation at the 3-position of 5-membered heteroaromatics

Irradiation of arenecarbothioamide with 5-membered heteroaromatics, including benzo-fused 5-membered ones, gave regioselectively the corresponding 3-aroyl derivatives.