702641-05-2

Basic information

• Product Name: 2-Iodo-5-(trifluoromethyl)benzyl alcohol
• Synonyms: 2-Iodo-5-(trifluoromethyl)benzyl alcohol;[2-Iodo-5-(trifluoromethyl)phenyl]methanol;5-(Trifluoromethyl)-2-iodobenzyl alcohol;BenzeneMethanol, 2-iodo-5-(trifluoroMethyl)-;[2-Iodo-5-(trifluoromethyl)phenyl]methanol, 3-(Hydroxymethyl)-4-iodobenzotrifluoride;2-iodo-5-(trifluoromethyl)phenyl]methano;(2-Iodo-5-(trifluoromethyl)
• CAS NO: 702641-05-2
• Molecular Formula: C₈H₆F₃IO
• Molecular Weight: 302.0323196
• Product Categories: Fluorine series
• Mol File: 702641-05-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 81-82℃
• Boiling Point: 271℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.901
• Storage Temp.: 2-8°C(protect from light)
• PKA: 13.82±0.10(Predicted)
• CAS DataBase Reference: 2-Iodo-5-(trifluoromethyl)benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-5-(trifluoromethyl)benzyl alcohol(702641-05-2)
• EPA Substance Registry System: 2-Iodo-5-(trifluoromethyl)benzyl alcohol(702641-05-2)

Safety Data

• Hazardous Substances Data: 702641-05-2(Hazardous Substances Data)

Usage

General Description

2-Iodo-5-(trifluoromethyl)benzyl alcohol is a chemical compound with the molecular formula C8H6F3IO. It is an organic compound that contains an alcohol functional group, a benzyl group, and a trifluoromethyl group. 2-Iodo-5-(trifluoromethyl)benzyl alcohol is used in organic synthesis and medicinal chemistry as a reagent and a building block for the synthesis of various pharmaceuticals and biologically active compounds. It is a white to off-white solid with a melting point of 42-45°C and is sparingly soluble in water, but soluble in organic solvents such as ethanol and acetone. 2-Iodo-5-(trifluoromethyl)benzyl alcohol has potential applications in the development of new pharmaceuticals and agrochemicals due to its unique structure and reactivity.

Upstream product

• 1483-56-3 2-bromo-5-(trifluoromethyl)benzoic acid 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 6526-08-5 2-amino-5-(trifluoromethyl)benzonitrile 
• 868166-20-5 2-iodo-5-(trifluoromethyl)benzonitrile 
• 220107-65-3 2-Amino-5-(trifluoromethyl)benzyl alcohol 
• 875446-23-4 2-iodo-5-(trifluoromethyl)benzaldehyde 
• 702641-04-1 2-iodo-5-(trifluoromethyl)benzoic acid 

Downstream Products

• 875549-49-8 (+)-(5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1312671-81-0 (-)-(5S)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1312671-76-3 (+)-(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,5-dimethyl-1,3-oxazolidin-2-one 
• 875548-98-4 2'-(bromomethyl)-4-fluoro-2-methoxy-5-(propan-2-yl)-4'-(trifluoromethyl)biphenyl 
• 1312671-75-2 5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 943917-82-6 (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-3'-iodo-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4-methyl-1,3-oxazolidin-2-one 
• 943917-81-5 (4S,5R)-3-{[3'-amino-4'-fluoro-4-(trifluoromethyl)biphenyl-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one 

Relevant articles and documents

Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)-H Arylation with a Transient Directing Group

Methylene-selective C-H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) catalysis. We report a Pd(II)-catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)-H arylation of ketones. The reaction utilizes glycine as a transient directing group and a 2-pyridone ligand, which may govern the methylene selectivity by making intimate molecular associations with the substrate during concerted metalation-deprotonation. This reaction is shown to be highly selective for intramolecular methylene C(sp3)-H arylation, thus enabling sequential C(sp3)-H functionalization.

Access to chiral tetrahydrofluorenes through a palladium-catalyzed enantioselective tandem intramolecular Heck/Tsuji-Trost reaction

A palladium-catalyzed enantioselective coupling of 2,5-cyclohexadienyl-substituted aryl iodides and carbon or heteroatom nucleophiles is described. The reaction proceeded via a tandem asymmetric Heck insertion and Tsuji-Trost allylation, enabling the rapi

Intermolecular domino reaction of two Aryl iodides involving two C-H functionalizations

A palladium-catalyzed intermolecular cross-coupling of two aryl iodides is reported, giving polycyclic ring systems with a high level of convergence and efficiency. Pendulum Reaction: 1 Pd complex catalyzes the intermolecular reaction of 2 aryl iodides to