70281-91-3

Upstream product

• 18595-97-6 5-amino-3-(3-hydroxypropyl)-4H-[1,2,4]triazole 
• 141-97-9 ethyl acetoacetate 
• 64-19-7 acetic acid 

Downstream Products

• 1013401-38-1 C₂₁H₁₉F₄N₅SO 
• 1013401-37-0 C₂₀H₂₀FN₅SO 
• 1013401-27-8 7-anilino-5-methyl-2-(3-(furan-2-ylmethylthio)propyl)-[1,2,4]triazolo[1,5-a]pyrimidine 
• 1013401-36-9 C₁₆H₁₄F₄ClN₅ 
• 1013401-35-8 C₁₅H₁₅FClN₅ 
• 1013401-26-7 7-anilino-5-methyl-2-(3-chloropropyl)-[1,2,4]-triazolo[1,5-a]pyrimidine 

Relevant academic research and scientific papers

Synthesis and anti-tumor activities of novel [1,2,4]triazolo[1,5-a] pyrimidines

A series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives has been designed and synthesized in order to find novel anti-tumor compounds. The structures of all the compounds were confirmed by IR, 1H-NMR, MS and elemental analysis. Their ant

Synthesis and cytotoxicity studies of novel [1,2,4] Triazolo [1,5-a]pyrimidine-7-amines

A series of novel N-anilino-5-methyl-2-(3-(5-(alkylaminomethyl)furan-2-yl- methylthio)propyl)-[1,2,4]triazolo-[1,5-a]pyrimidine-7-amine derivatives were synthesized and evaluated for their in vitro cytotoxicity against two cancer cell lines, Bel-7402 and HT-1080. Compounds 9, 14, 19 and 23 possessed marked cytotoxicity, especially 23 (with IC50 values of 15.0μM and 7.8μM against Bel-7402 and HT-1080 cell lines, respectively), which had emerged as lead compound. The activity was found to depend strongly on substitution pattern of the side chains at C-2 position, and 4-triflouromethylanilino substituent at C-7 position was an option for anticancer potency.