18595-97-6

Usage

Uses

Used in Pharmaceutical Research and Development:
3-(5-AMINO-4H-[1,2,4]TRIAZOL-3-YL)-PROPAN-1-OL is used as a building block for the synthesis of various drugs and bioactive compounds due to its unique structure and the presence of the amino group in the triazole ring.
Used in Medicinal Chemistry:
3-(5-AMINO-4H-[1,2,4]TRIAZOL-3-YL)-PROPAN-1-OL is used as a versatile compound in medicinal chemistry for the development of new pharmaceuticals, thanks to the hydroxyl group attached to the propane chain, which allows for easy modification and utilization in drug discovery processes.
Used in Drug Synthesis:
3-(5-AMINO-4H-[1,2,4]TRIAZOL-3-YL)-PROPAN-1-OL is used as a key intermediate in the synthesis of various pharmaceuticals, leveraging its structural features to create novel and effective drug candidates for treating a range of medical conditions.

InChI:InChI=1/C5H10N4O/c6-5-7-4(8-9-5)2-1-3-10/h10H,1-3H2,(H3,6,7,8,9)

Upstream product

• 96-48-0 4-butanolide 
• 79-17-4 aminoguanidine 

Downstream Products

• 70281-91-3 7-hydroxy-2-(3-hydroxypropyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine 
• 924213-28-5 (5-fluoro-2-hydroxyphenyl)[2-(3-hydroxypropyl)[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methanone 
• 1013401-38-1 C₂₁H₁₉F₄N₅SO 
• 1013401-37-0 C₂₀H₂₀FN₅SO 
• 1013401-27-8 7-anilino-5-methyl-2-(3-(furan-2-ylmethylthio)propyl)-[1,2,4]triazolo[1,5-a]pyrimidine 
• 1013401-36-9 C₁₆H₁₄F₄ClN₅ 
• 1013401-35-8 C₁₅H₁₅FClN₅ 
• 1013401-26-7 7-anilino-5-methyl-2-(3-chloropropyl)-[1,2,4]-triazolo[1,5-a]pyrimidine 

Relevant academic research and scientific papers

Synthesis and cytotoxicity studies of novel [1,2,4] Triazolo [1,5-a]pyrimidine-7-amines

A series of novel N-anilino-5-methyl-2-(3-(5-(alkylaminomethyl)furan-2-yl- methylthio)propyl)-[1,2,4]triazolo-[1,5-a]pyrimidine-7-amine derivatives were synthesized and evaluated for their in vitro cytotoxicity against two cancer cell lines, Bel-7402 and HT-1080. Compounds 9, 14, 19 and 23 possessed marked cytotoxicity, especially 23 (with IC50 values of 15.0μM and 7.8μM against Bel-7402 and HT-1080 cell lines, respectively), which had emerged as lead compound. The activity was found to depend strongly on substitution pattern of the side chains at C-2 position, and 4-triflouromethylanilino substituent at C-7 position was an option for anticancer potency.

Synthesis and anti-tumor activities of novel [1,2,4]triazolo[1,5-a] pyrimidines

A series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives has been designed and synthesized in order to find novel anti-tumor compounds. The structures of all the compounds were confirmed by IR, 1H-NMR, MS and elemental analysis. Their ant