18595-97-6 Usage
General Description
3-(5-amino-4H-[1,2,4]triazol-3-yl)-propan-1-ol is a chemical compound with a structure consisting of a 1,2,4-triazole ring fused to a propane chain, with an amino group attached to the triazole ring. 3-(5-AMINO-4H-[1,2,4]TRIAZOL-3-YL)-PROPAN-1-OL is classified as a triazole derivative and is commonly used in pharmaceutical research and development due to its potential medicinal properties. The presence of the amino group in the structure makes it a versatile building block for the synthesis of various drugs and bioactive compounds. Additionally, the hydroxyl group attached to the propane chain allows for the compound to be easily modified and utilized in the development of new pharmaceuticals. Overall, 3-(5-amino-4H-[1,2,4]triazol-3-yl)-propan-1-ol has great potential in medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 18595-97-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,5,9 and 5 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 18595-97:
(7*1)+(6*8)+(5*5)+(4*9)+(3*5)+(2*9)+(1*7)=156
156 % 10 = 6
So 18595-97-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H10N4O/c6-5-7-4(8-9-5)2-1-3-10/h10H,1-3H2,(H3,6,7,8,9)
18595-97-6Relevant articles and documents
Synthesis and cytotoxicity studies of novel [1,2,4] Triazolo [1,5-a]pyrimidine-7-amines
Zhai, Xin,Zhao, Yan-Fang,Liu, Ya-Jing,Zhang, Yong,Xun, Feng-Qiang,Liu, Jun,Gong, Ping
experimental part, p. 941 - 945 (2009/07/18)
A series of novel N-anilino-5-methyl-2-(3-(5-(alkylaminomethyl)furan-2-yl- methylthio)propyl)-[1,2,4]triazolo-[1,5-a]pyrimidine-7-amine derivatives were synthesized and evaluated for their in vitro cytotoxicity against two cancer cell lines, Bel-7402 and HT-1080. Compounds 9, 14, 19 and 23 possessed marked cytotoxicity, especially 23 (with IC50 values of 15.0μM and 7.8μM against Bel-7402 and HT-1080 cell lines, respectively), which had emerged as lead compound. The activity was found to depend strongly on substitution pattern of the side chains at C-2 position, and 4-triflouromethylanilino substituent at C-7 position was an option for anticancer potency.
