70299-30-8Relevant academic research and scientific papers
Iron-catalyzed 2 - benzenes and wicked zuozuo apperception for the synthesis of the new method
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Paragraph 0019-0020; 0049-0050, (2018/01/11)
The invention discloses a new synthesis method of iron-catalyzed 2-aryl benzoxazoles, which is prepared by directly performing C-N coupling and C-O coupling on benzamide and o-bromoiodobenzene serving as raw materials at a certain temperature in the presence an iron salt, a ligand and an alkali. According to the invention, a biological metal iron is introduced in synthesis of medical skeletons 2-aryl benzoxazoles, thus use of high-toxicity metals like palladium is avoided, and the application range of the method is expanded to substrates containing different substituent groups. The invention also successfully develops a catalyzing system which can have a catalysis effect on C-N and C-O coupling at the same time, and can greatly improve the safety of 2-aryl benzoxazoles in the synthesis process.
Copper-catalysed intramolecular O-arylation: A simple and efficient method for benzoxazole synthesis
Wu, Fengtian,Zhang, Jie,Wei, Qianbing,Liu, Ping,Xie, Jianwei,Jiang, Haojie,Dai, Bin
supporting information, p. 9696 - 9701 (2015/02/19)
A wide range of 2-substituted benzoxazoles can be efficiently synthesized from N-(2-iodo-/bromo-phenyl)benzamides, and even the less reactive N-(2-chlorophenyl)benzamides, via Cu-catalysed intramolecular coupling cyclization reactions using methyl 2-methoxybenzoate as the ligand under mild reaction conditions. In addition, the benzoxazoles can be easily prepared from the primary amides coupling with o-dihalobenzenes in a single step. This journal is
Organocatalytic syntheses of benzoxazoles and benzothiazoles using aryl iodide and oxone via C-H functionalization and C-O/S bond formation
Alla, Santhosh Kumar,Sadhu, Pradeep,Punniyamurthy, Tharmalingam
, p. 7502 - 7511 (2014/09/16)
An organocatalytic protocol for the syntheses of 2-substituted benzoxazoles and benzothiazoles is described from alkyl-/arylanilides and alkyl-/arylthioanilides using 1-iodo-4-nitrobenzene as catalyst and oxone as an inexpensive and environmentally safe terminal oxidant at room temperature in air via oxidative C-H functionalization and C-O/S bond formation. The procedure is simple and general and provides an effective route for the construction of functionalized 2-alkyl-/arylbenzoxazoles and 2-alkyl-/arylbenzothiazoles with moderate to high yields. The synthetic and mechanistic aspects have been described.
Site-selective Suzuki-Miyaura reactions of 2,6-dichlorobenzoxazole
Hamdy, Aws M.,Eleya, Nadi,Mohammed, Hamid H.,Patonay, Tamás,Spannenberg, Anke,Langer, Peter
, p. 2081 - 2086 (2013/03/13)
Suzuki-Miyaura reactions of 2,6-dichlorobenzoxazole provide a convenient access to arylated benzoxazoles. The reactions proceed with excellent site-selectivity in favour of position 2, due to electronic reasons.
Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases
Wisastra, Rosalina,Ghizzoni, Massimo,Boltjes, Andre,Haisma, Hidde J.,Dekker, Frank J.
supporting information; experimental part, p. 5027 - 5032 (2012/09/22)
Lipoxygenases catalyze the oxidation of unsaturated fatty acids, such as linoleic acid, which play a crucial role in inflammatory responses. Selective inhibitors may provide a new therapeutic approach for inflammatory diseases. In this study, we describe
