7595-61-1

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-chlorophenyl)-4-methoxybenzamide is used as a pharmaceutical agent for its anti-inflammatory and analgesic properties. Its chemical structure allows it to modulate various biological pathways, making it a promising candidate for the development of new drugs to treat pain and inflammation.
Used in Cancer Research:
In the field of cancer research, N-(4-chlorophenyl)-4-methoxybenzamide is used as a potential anticancer agent. Its ability to target specific cellular mechanisms and pathways may contribute to the development of novel therapeutic strategies for the treatment of various types of cancer.
Used in Neurological Disorders Research:
N-(4-chlorophenyl)-4-methoxybenzamide is also used in the research of neurological disorders. Its potential neuroprotective and neuroregenerative properties make it a candidate for the development of treatments for conditions such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.
Overall, N-(4-chlorophenyl)-4-methoxybenzamide shows promise in various fields due to its chemical structure and potential pharmacological activities, making it a valuable compound in research and pharmaceutical industries.

InChI:InChI=1/C14H12ClNO2/c1-18-13-8-2-10(3-9-13)14(17)16-12-6-4-11(15)5-7-12/h2-9H,1H3,(H,16,17)

Upstream product

• 106-47-8 4-chloro-aniline 
• 100-07-2 4-methoxy-benzoyl chloride 
• 24056-08-4 N-methoxy-4-methoxylbenzamide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 37155-52-5 1-(4-chlorobenzyl)-4-methoxybenzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 3424-93-9 4-methoxyphenylacetamide 
• 2393-23-9 4-methoxy-benzylamine 
• 107947-24-0 (4-chlorophenyl)(4-methoxyphenyl)methanone oxime 
• 122081-19-0 4-Methoxy-benzoic acid [2-[(Z)-hydroxyimino]-1-methyl-prop-(Z)-ylidene]-hydrazide 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 100-09-4 4-methoxybenzoic acid 

Downstream Products

• 1017572-81-4 (Z)-4-chloro-N-(1-(4-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynylidene)aniline 
• 70299-30-8 6-chloro-2-(4-methoxyphenyl)benzo[d]oxazole 
• 154558-90-4 6-chloro-2-(4-methoxyphenyl)benzo[d]thiazole 
• 127351-02-4 N-(4-chlorophenyl)-4-methoxybenzothioamide 

Relevant academic research and scientific papers

Iron-catalyzed cross-coupling of N?methoxy amides and arylboronic acids for the synthesis of N-aryl amides

An efficient iron-catalyzed synthesis of N-aryl amides from N?methoxy amides and arylboronic acids is developed. FeCl3 is used as the sole catalyst for the cross-coupling reaction between N?methoxy amides and arylboronic acids without any other

Integration of co2 reduction with subsequent carbonylation: Towards extending chemical utilization of co2

Currently, it still remains a challenge to amplify the spectrum of chemical fixation of CO2, although enormous progress has been achieved in this field. In view of the widespread applications of CO in a myriad of industrial carbonylation processes, an alternative strategy is proposed in which CO2 reduction to CO is combined with carbonylation with CO generated ex situ, which affords efficiently pharmaceutically and agrochemically attractive molecules. As such, CO2 in this study was efficiently reduced by triphenysilane using CsF to CO in a sealed two-chamber reactor. Subsequently, palladium-catalyzed aminocar-bonylation, carbonylative Sonogashira coupling of aryl iodides, and rhodium(I)-mediated Pauson–Khand-type reaction proceeded smoothly to yield amides, alkynones, and bicyclic cy-clopentenones, respectively. Furthermore, the formed alkynones can further be successfully converted to a series of heterocycles, for example, pyrazoles, 3a-hydroxyisoxazolo[3,2-a]isoindol-8-(3aH)-one derivatives and pyrimidines in moderate yields. The striking features of this protocol include operational simplicity, high efficiency, and relatively broad application scope, which represents an alternative avenue for CO2 transformation.

Hypervalent Iodine-Mediated Oxidative Rearrangement of N-H Ketimines: An Umpolung Approach to Amides

An umpolung approach to amides via hypervalent iodine-mediated oxidative rearrangement of N-H ketimines under mild reaction conditions is described. This strategy provides target amides with excellent selectivity in good yields. In addition, preliminary m

Efficient and Mild Ullmann-Type N-Arylation of Amides, Carbamates, and Azoles in Water

A simple, sustainable, efficient, mild, and low-cost protocol was developed for d-glucose-assisted Cu-catalyzed Ullmann reactions in water for amides, carbamates, and nitrogen-containing heterocycles. The reaction was compatible with diverse aryl/heteroaryl iodides, giving highly substituted pyridine, indole, or indazole rings. This method offers an attractive alternative to existing protocols, because the reaction proceeds in aqueous media, occurs at or near ambient temperature, and provides the N-arylated products in good to high yields.

DDQ-promoted direct transformation of benzyl hydrocarbons to amides via tandem reaction of the CDC reaction and Beckmann rearrangement

An atom-efficient and transition metal-free approach to amides from the corresponding benzyl hydrocarbons through C-H and C-C bond cleavage has been developed. Mechanistic studies have shown that a DDQ-promoted cross-dehydrogenative coupling (CDC) reaction with subsequent oxidation and rearrangement are involved in this transformation. The Royal Society of Chemistry.

Efficient manganese/copper bimetallic catalyst for N-arylation of amides and sulfonamides under mild conditions in water

An efficient and mild method using a bimetallic MnF2/CuI catalyst at 60 °C in water was developed for the N-arylation of amides and sulfonamides with aryl halides. A variety of functionalized amides and sulfonamides were coupled with different substituted aryl halides to afford the corresponding N-arylated products in good to excellent yields (up to 97 %). An efficient method using a bimetallic MnF2/CuI catalyst in combination with trans-1,2-diaminocyclohexane as the ligand has been developed for the cross-coupling of benzamides and sulfonamides with differently substituted aryl iodides in water. The corresponding N-arylated products were obtained in good to excellent yields (up to 97 %) under the catalytic conditions. Copyright

The synthesis of N-arylated amides via copper(II) triflate-catalyzed direct oxygenation and N-arylation of benzylamines with aryl iodides

An efficient approach for the synthesis of N-arylated amides by copper(II) triflate-catalyzed direct oxygenation and N-arylation reaction of benzylamines with aryl iodides is reported. Various benzylamines and aryl iodides can participate in the reaction, providing a series of N-arylated amides in moderate to good yields.

The synthesis of N-arylated amides via copper(II) triflate-catalyzed direct oxygenation and N-arylation of benzylamines with aryl iodides

An efficient approach for the synthesis of N-arylated amides by copper(II) triflate-catalyzed direct oxygenation and N-arylation reaction of benzylamines with aryl iodides is reported. Various benzylamines and aryl iodides can participate in the reaction, providing a series of N-arylated amides in moderate to good yields.

Facile AlCl3-promoted catalytic beckmann rearrangement of ketoximes

Aluminum chloride, an inexpensive and commercially available Lewis acid traditionally employed for Beckmann rearrangement with stoichiometric amounts, has been now found to smoothly promote the Beckmann rearrangement of various ketoximes to the corresponding amides (up to 99% of yield) with 10mol% catalyst loading in anhydrous acetonitrile under reflux temperature.

A mild and highly efficient catalyst for Beckmann rearrangement, BF 3·OEt2

BF3·OEt2 (Boron trifluoride etherate), an inexpensive and commercially easily available Lewis acid stoichiometrically employed for Beckamann rearrangement in general, was now found to efficiently catalyze Beckmann rearrangement of ketoximes into their corresponding amides (up to 99% yield) in anhydrous acetonitrile under reflux temperature.