70301-49-4Relevant academic research and scientific papers
Synthesis of gem-difluorocyclopentane/hexane building blocks
Melnykov, Kostiantyn P.,Nosik, Pavel S.,Kurpil, Bohdan B.,Sibgatulin, Dmitriy A.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Grygorenko, Oleksandr O.
, p. 60 - 66 (2017/05/17)
An approach to the preparation of gem-difluorocyclopentane/hexane-derived carboxylic acids and amines is described. Whereas for 3,3-difluoro-substituted cycloalkanones, straightforward deoxofluorination of the corresponding ketoesters led to the target compounds, in the case of 2,2-difluoro isomers, the bypass or alternative routes were necessary.
The enantioselective synthesis of tetracyclic methyllycaconitine analogues
Sparrow, Kevin,Barker, David,Brimble, Margaret A.
experimental part, p. 7989 - 7999 (2011/11/07)
A new enantioselective synthesis of ABEF ring analogues of methyllycaconitine has been developed using a chiral cobalt(III) salen-catalyzed Diels-Alder reaction to form the B ring. Subsequent elaboration to form the A, E and F rings was achieved by sequential Dieckmann, Mannich and Wacker-type cyclizations to afford tetracyclic analogues in 97.5% ee.
Synthesis and identification of hydroxylated metabolites of the anti-estrogenic agent cyclofenil
Gaertner, Peter,Hofbauer, Karin,Reichel, Christian,Geisendorfer, Thomas,Gmeiner, Guenter
scheme or table, p. 958 - 964 (2009/05/07)
The detection of metabolites of the anti-estrogenic substance cyclofenil, listed on the World Anti-Doping Agency (WADA) Prohibited List since 2004 is described. Target substances are hydroxylated metabolites, bearing an aliphatic hydroxyl group either in the 2-, 3- or 4-position of the aliphatic ring, in addition to the phenolic functions on the aromatic rings. Structural identification used NMR as well as high-resolution mass spectrometry after nano-electrospray ionisation (ESI). Unambiguous detection of all three synthesised cyclofenil metabolites M1-M3 was done using gas chromatography for separation and electron ionisation mass spectrometry for detection of the per-silylated compounds in comparison with a reference urine deriving from an excretion study within the WADA 2007 Educational Programme. Copyright
Possibilities of Synthesizing 3-N-Alkyl Derivatives of 2-Thiouracils under Basic and Acidic Condensation Conditions. Selective Synthesis of New 3-N-Allyl-5,6-dialkyl-2-thiouracils
Turski, K.,Draminski, M.
, p. 1973 - 1980 (2007/10/02)
It has been found out that the reaction of N-allylthiourea with α-alkyl-substituted β-ketoesters in the presence of sodium ethylate is partly selective. The use of the acetals of the initial ketoesters and acid catalysis allows to introduce the allyl subs
STEREOCHEMICAL STUDIES-XXVI CONFORMATIONAL EQUILIBRIA OF KETALS OF 2-SUBSTITUTED CYCLOHEXANONES
Mursakulov, Ismail G.,Guseinov, M. M.,Kasumov, N. K.,Zefirov, Nikolai S.,Samoshin, V. V.,Chalenko, E. G.
, p. 2213 - 2220 (2007/10/02)
The positions of the conformational equilibria in a series of 2-substituted cyclohexanone ketals have been determined by 1H NMR.For the ethylene ketals 6 the equatorial conformer has been found to be enthalpically preferred.The other ketal syst
