7035-53-2

Upstream product

• 1073-72-9 4-hydroxythioanisole 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 65136-52-9 4-(3-chloropropoxy)benzoic acid 
• 111626-84-7 α,α-[Bis(4-fluorophenyl)]-1-[3-[4-(methylsulfonyl)phenoxy]propyl]-4-piperidinemethanol fumarate 
• 117023-59-3 Bis-(4-fluoro-phenyl)-{1-[3-(4-methanesulfinyl-phenoxy)-propyl]-piperidin-4-yl}-methanol; compound with oxalic acid 
• 111627-51-1 1-(3-chloropropoxy)-4-(methylsulfonyl)benzene 
• 111627-56-6 1-(3-chloropropoxy)-4-(methylsulfinyl)benzene 
• 111626-82-5 α,α-[bis(4-fluorophenyl)]-1-[3-[4-(methylthio)phenoxy]propyl]-4-piperidinemethanol 

Relevant academic research and scientific papers

Synthesis and Antiallergy Activity of 4-(Diarylhydroxymethyl)-1-piperidines and Structurally Related Compounds

A series of 4-(diarylhydroxymethyl)-1-piperidines was synthesized and evaluated for antiallergy activity.Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity.In particular 1--1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.

ALKYLTHIOPHENOXYALKYLAMINES AND THE PHARMACEUTICAL USE THEREOF

A new class of alkylthiophenoxyalkylamine derivatives and methods for preparation are described. The compounds have vasodilating and antispasmodic activity, inhibit blood platelet aggregation and are substantially free of beta-adrenergic blocking effects. They are particularly valuable in the treatment of disease states responsive to vasodilation such as obstructive peripheral vascular diseases and cerebral vascular deficiencies. Representative and preferred embodiments of the invention are N-3-4-(methylthio)phenoxy!propyl!octylamine and N-3-4-(1-methylethyl)thio!phenoxy!-propyl!octylamine.