65136-52-9

Basic information

• Product Name: 4-Chloro-3-propoxybenzoic acid
• Synonyms: 4-Chloro-3-propoxybenzoic acid
• CAS NO: 65136-52-9
• Molecular Formula: C₁₀H₁₁ClO₃
• Molecular Weight: 214.64554
• Mol File: 65136-52-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 157 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 368.1±17.0 °C(Predicted)
• Appearance: /
• Density: 1.259±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 4.45±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-3-propoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-propoxybenzoic acid(65136-52-9)
• EPA Substance Registry System: 4-Chloro-3-propoxybenzoic acid(65136-52-9)

Safety Data

• Hazardous Substances Data: 65136-52-9(Hazardous Substances Data)

Usage

General Description

4-Chloro-3-propoxybenzoic acid is a chemical compound with the molecular formula C10H11ClO3. It is a derivative of benzoic acid with a chlorine atom and a propoxy group attached to the benzene ring. 4-Chloro-3-propoxybenzoic acid is commonly used in the synthesis of pharmaceuticals and as a building block in organic chemistry. It has been studied for its potential biological activities, including its antimicrobial and anti-inflammatory properties. In addition, 4-Chloro-3-propoxybenzoic acid may have potential applications in the development of new drugs and materials due to its unique chemical structure and reactivity.

Upstream product

• 109-70-6 1.3-chlorobromopropane 
• 99-96-7 4-hydroxy-benzoic acid 
• 7035-53-2 1-chloro-3-[4-(methylthio)phenoxy]propane 
• 124-38-9 carbon dioxide 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 75912-94-6 4-(3-chloropropoxy)benzoic acid ethyl ester 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 69076-29-5 4-(3-chloropropoxy)benzoic acid methyl ester 

Downstream Products

• 65136-48-3 4-(3-chloropropoxy)benzoic acid chloride 
• 250679-75-5 N-{5-[4-(3-chloropropoxy)benzamido]-2-methylphenyl}-3,4-dimethoxybenzamide 

Relevant articles and documents

Ni-Catalyzed Carboxylation of C(sp2)-S Bonds with CO2: Evidence for the Multifaceted Role of Zn

Nickel-catalyzed reductive carboxylation reactions of aryl electrophiles typically require the use of metallic reducing agents. At present, the prevailing perception is that these serve as both a source of electrons and as a source of Lewis acids that may aid CO2 insertion into the Ni-C bond. Herein, we provide evidence for the in situ formation of organometallic species from the metallic reductant, a step that has either been ruled out or has been unexplored in catalytic carboxylation reactions with metal powder reductants. Specifically, we demonstrate that Zn(0) acts as a reductant and that Zn(II) generates arylzinc species that might play a role in the C(sp2)-S carboxylation of arylsulfonium salts. Overall, the reductive Ni-catalyzed C(sp2)-S carboxylation reaction proceeds under mild conditions in a non-amide solvent, displays a wide substrate scope, and can be applied to the formal para C-H carboxylation of arenes.

Preparation and applications of phenylquinolinone-based and flavone-based derivative

The present invention relates to a phenylquinolinone-based and flavone-based derivative and a preparation method thereof, wherein the derivative is a histamine H3 receptor antagonist, can protect andrestore the normal function of central nervous system, e