7038-75-7

Usage

Uses

Used in Chemical Research:
4-Pyrimidinol, 6-cyclopropyl(7CI,8CI) is used as a building block for the synthesis of various organic molecules, contributing to the advancement of chemical research.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-Pyrimidinol, 6-cyclopropyl(7CI,8CI) serves as a key component in the development of new drugs, thanks to its unique cyclopropyl group and potential medicinal properties.

Upstream product

• 4765-77-9 4-chloro-6-hydroxypyrimidine 
• 411235-57-9 cyclopropylboronic acid 
• 32249-35-7 methyl 3-cyclopropyl-3-oxopropanoate 
• 463-52-5 formamidine 
• 3473-63-0 formamidine acetic acid 

Relevant academic research and scientific papers

NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS

The present disclosure provides compounds having Formula (I): (I) and the pharmaceutically acceptable salts and solvates thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R6, R6', R7, and R7' are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to inhibit a USP1 protein and/or to treat a disorder responsive to the inhibition of USP1 proteins and USP1 activity. Compounds of the present disclosure are especially useful for treating cancer.

COMPOUNDS AS MODULATORS OF ROR GAMMA

The present invention encompasses compounds of the formula (I)(I) wherein the variables are defined herein which are suitable for the modulation of RORγ and the treatment of diseases related to the modulation of RORγ. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

AZAINDOLE COMPOUNDS AS MODULATORS OF RORC

The present invention encompasses compounds of the formula (I), wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

COMPOUNDS AS MODULATORS OF ROR GAMMA

The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of RORγ and the treatment of diseases related to the modulation of RORγ. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.