70380-73-3 Usage
Description
5-(2-PYRIDYL)-1,3-OXAZOLE is a heterocyclic organic compound characterized by the molecular formula C9H7N2O. It features a pyridine ring fused with an oxazole ring, endowing it with unique chemical and biological properties. 5-(2-PYRIDYL)-1,3-OXAZOLE is widely recognized for its role as a building block in pharmaceutical and organic synthesis, as well as for its diverse applications in various scientific fields.
Uses
Used in Pharmaceutical Industry:
5-(2-PYRIDYL)-1,3-OXAZOLE is utilized as a key component in the development of pharmaceutical drugs due to its biological activities. It serves as a valuable building block for the synthesis of various drugs, contributing to their antibacterial, antifungal, and anticancer properties. Its presence in drug molecules enhances their therapeutic efficacy and helps in addressing various health challenges.
Used in Organic Synthesis:
In the realm of organic synthesis, 5-(2-PYRIDYL)-1,3-OXAZOLE is employed as a versatile intermediate for the preparation of fine chemicals. Its unique structure allows for the formation of diverse chemical entities, making it an essential component in the synthesis of complex organic compounds.
Used in Analytical Chemistry:
5-(2-PYRIDYL)-1,3-OXAZOLE is used as a fluorescent indicator in analytical chemistry. Its ability to emit fluorescence upon interaction with specific analytes makes it a valuable tool for detecting and quantifying target molecules in various samples. This property is particularly useful in the development of sensitive and selective analytical methods.
Used in Coordination Chemistry:
In coordination chemistry, 5-(2-PYRIDYL)-1,3-OXAZOLE functions as a ligand, forming coordination complexes with metal ions. Its bidentate nature allows for stable complex formation, which is crucial in various applications, such as catalysis, sensing, and materials science. The use of this compound as a ligand contributes to the advancement of coordination chemistry and the development of novel materials with unique properties.
Safety Considerations:
Given its flammable nature, 5-(2-PYRIDYL)-1,3-OXAZOLE should be handled with care in a controlled laboratory environment. Proper safety measures, such as the use of personal protective equipment and adherence to safety protocols, are essential to minimize risks associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 70380-73-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,3,8 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 70380-73:
(7*7)+(6*0)+(5*3)+(4*8)+(3*0)+(2*7)+(1*3)=113
113 % 10 = 3
So 70380-73-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H6N2O/c1-2-4-10-7(3-1)8-5-9-6-11-8/h1-6H
70380-73-3Relevant articles and documents
Convergent and Practical Synthesis of Fluorescent Triphenylamine Derivatives and Their Localization in Living Cells
Auvray, Marie,Franck, Xavier,Gallavardin, Thibault,Leleu, Stéphane,Mahuteau-Betzer, Florence,Mougeot, Romain,Oger, Samuel
supporting information, (2022/02/09)
In the search for new fluorescent triphenylamine (TP) derivatives, we studied the influence of the position and substitution of diverse heterocyclic substituents. A library of 10 fluorescent triphenylamines bearing either oxazoles or thiazoles and pyridiniums, substituted at different positions has been developed. The approach is based on a convergent C?H activation reaction between pyridine-oxazoles or pyridine-thiazoles and di-iodo triphenylamine. We showed that the nature and substitution pattern of the 5-membered- (oxazole, thiazole) or 6-membered heterocycle (pyridine) has a strong influence on their fluorescence properties and on their localization in living cells as they stain either the nucleus or mitochondria.
Improvement of the Van Leusen reaction in the presence of β-cyclodextrin: A green and efficient synthesis of oxazoles in water
Rahimzadeh, Golnaz,Kianmehr, Ebrahim,Mahdavi, Mohammad
, p. 923 - 926 (2017/12/18)
An efficient approach for the synthesis of oxazoles through the Van Leusen reaction in the presence of β-cyclodextrin is described. In aqueous medium using β-cyclodextrin as a supramolecular catalyst, tosylmethyl isocyanide was deprotonated by triethylami
Linear and Branched Pyridyl-Oxazole Oligomers: Synthesis and Circular Dichroism Detectable Effect on c-Myc G-Quadruplex Helicity
Rizeq, Natalia,Georgiades, Savvas N.
, p. 122 - 131 (2016/01/26)
Five unprecedented pyridyl-oxazole oligomers exhibiting either linear or branched connectivity of their subunits were developed as a family of potential G-quadruplex-interacting ligands. Our synthesis employed variations of a key Pd/Cu-mediated C-C cross-coupling/C-H activation reaction to gain access to the oligomer products from a small set of substituted pyridine building blocks. The effect of the compounds on the conformation of a c-myc oncogene promoter G-quadruplex was investigated by circular dichroism under various conditions. Some or all of the compounds induced detectable helicity enhancement in low-cation and Na+-rich Tris-HCl (pH 7.4) buffers, respectively, in which the helix was only partially prefolded.
