70393-62-3

Basic information

• Product Name: 7-Hydroxylauric acid
• Synonyms: 7-Hydroxydodecanoic acid;7-Hydroxylauric acid
• CAS NO: 70393-62-3
• Molecular Formula: C12H24O3
• Molecular Weight: 216.32
• Mol File: 70393-62-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Hydroxylauric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Hydroxylauric acid(70393-62-3)
• EPA Substance Registry System: 7-Hydroxylauric acid(70393-62-3)

Safety Data

• Hazardous Substances Data: 70393-62-3(Hazardous Substances Data)

Upstream product

• 143-07-7 lauric acid 
• 53293-00-8 hex-5-ynoic acid 
• 66-25-1 hexanal 
• 58262-36-5 Ethyl 7-oxododecanoate 
• 33018-91-6 7-ethoxy-7-oxoheptanoic acid 
• 14794-32-2 ethyl 6-(chloroformyl)hexanoate 
• 629-25-4 Sodium laurate 
• 54527-26-3 7-oxododecanoic acid 
• 78672-91-0 (R)-(-)-5-dodecyn-7-ol 
• 473545-75-4 (R)-1-Dodecyn-7-ol 

Relevant articles and documents

Succinct synthesis of saturated hydroxy fatty acids and: In vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84

Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.

A series of hybrid P450 BM3 enzymes with different catalytic activity in the light-initiated hydroxylation of lauric acid

We have developed a series of hybrid P450 BM3 enzymes to perform the light-activated hydroxylation of lauric acid. These enzymes contain a Ru(II)-diimine photosensitizer covalently attached to single cysteine residues of mutant P450 BM3 heme domains. The library of hybrid enzymes includes four non-native single cysteine mutants (K97C, Q397C, Q109C and L407C). In addition, mutations around the heme active site, F87A and I401P, were inserted in the Q397C mutant. Two heteroleptic Ru(II) complexes, Ru(bpy)2phenA (1) and Ru(phen)2phenA (2) (bpy = bipyridine, phen = 1,10-phenanthroline, and phenA = 5-acetamido-1,10-phenanthroline), are used as photosensitizers. Upon visible light irradiation, the hybrid enzymes display various total turnover numbers in the hydroxylation of lauric acid, up to 140 for the L407C-1 mutant, a 16-fold increase compared to the F87A/Q397C-1 mutant. CO binding studies confirm the ability of the photogenerated Ru(I) compound to reduce the fraction of ferric high spin species present in the mutants upon substrate binding.

Asymmetric Synthesis of Hydroxy Carboxylic Acids

Optically-active hydroxy carboxylic acids of the general formula RCHOH(CH2)nCO2H are prepared from optically-active propargyl alcohols.