70415-72-4

Basic information

• Product Name: Benzoic acid, 4-methoxy-, 2-pyridinylmethyl ester
• CAS NO: 70415-72-4
• Molecular Formula: C14H13NO3
• Molecular Weight: 243.262
• Mol File: 70415-72-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-methoxy-, 2-pyridinylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-methoxy-, 2-pyridinylmethyl ester(70415-72-4)
• EPA Substance Registry System: Benzoic acid, 4-methoxy-, 2-pyridinylmethyl ester(70415-72-4)

Safety Data

• Hazardous Substances Data: 70415-72-4(Hazardous Substances Data)

Upstream product

• 696-62-8 para-iodoanisole 
• 401515-97-7 2-pyridylmethyl formate 
• 586-98-1 2-Hydroxymethylpyridine 
• 201230-82-2 carbon monoxide 
• 109-06-8 α-picoline 
• 100-09-4 4-methoxybenzoic acid 

Downstream Products

• 586-98-1 2-Hydroxymethylpyridine 
• 100-66-3 methoxybenzene 

Relevant articles and documents

Nickel-catalyzed alkoxycarbonylation of aryl iodides with 1 atm CO

A nickel-catalyzed alkoxycarbonylation of aromatic iodides with alcohols under atmospheric pressure of carbon monoxide is presented here. This operationally simple protocol allows the facile synthesis of (hetero)aromatic esters, exhibiting broad substrate scope with excellent functional group tolerance. Various primary and secondary aliphatic alcohols as well as phenols are suitable for this transformation.

Practical: In situ -generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters

An effective method for alkoxycarbonylation of (hetero)aryl bromides is developed in the presence of in situ-generated phosphinite ligands tBu2POR (R = nBu, nPr, Et or Me). For this purpose commercially available tBu2PCl was used as the pre-ligand in the presence of different alcohols. For the first time cross coupling reactions with two alcohols-one generating the ligand, the other used as substrate-were developed. Through this method, ligand optimization can be performed in a more efficient manner and the desired products could be obtained with good yields and selectivity.