70419-06-6Relevant articles and documents
Catalytic Asymmetric Addition of Organolithium Reagents to Aldehydes
Veguillas, Marcos,Solà, Ricard,Shaw, Luke,Maciá, Beatriz
, p. 1788 - 1794 (2016/04/05)
Herein we report an efficient catalytic system for the titanium-promoted enantioselective addition of organolithium reagents to aldehydes, based on chiral Ar-BINMOL ligands. Unprecedented yields and enantioselectivities are achieved in the alkylation reactions of aliphatic aldehydes. Remarkably, methyllithium can be added to a wide variety of aromatic and aliphatic aldehydes, providing versatile chiral methyl carbinol units in a simple one-pot procedure under mild conditions and in very short reaction times.
Catalytic enantioselective addition of methyltriisopropoxititanium to aldehydes
Veguillas, Marcos,Solà, Ricard,Fernández-Iba?ez, M. ángeles,Maciá, Beatriz
, p. 643 - 648 (2016/07/11)
An efficient catalyst for the enantioselective synthesis of chiral methyl carbinols from aldehydes is presented. The system uses methyltriisopropoxytitanium as a nucleophile and a readily available binaphthyl derivative as a chiral ligand. The enantioselective methylation of both aromatic and aliphatic aldehydes proceeds with good yields and high enantioselectivities under mild conditions.
Identification of key residues in Debaryomyces hansenii carbonyl reductase for highly productive preparation of (S)-aryl halohydrins
Xu, Guo-Chao,Shang, Yue-Peng,Yu, Hui-Lei,Xu, Jian-He
supporting information, p. 15728 - 15731 (2015/11/02)
Key residues of Debaryomyces hansenii carbonyl reductase in the determination of the reducing activity towards aryl haloketones were identified through combinatorial mutation of conserved residues. This study provides a green and efficient biocatalyst for the synthesis of (S)-aryl halohydrins.