70458-94-5

Basic information

• Product Name: ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE
• Synonyms: ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE;Ethyl 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate;Norfloxacin Impurity 5
• CAS NO: 70458-94-5
• Molecular Formula: C₁₄H₁₃ClFNO₃
• Molecular Weight: 297.71
• Mol File: 70458-94-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 139-141 °C
• Boiling Point: 425.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• Storage Temp.: Room Temperature
• Solubility: Dichloromethane, DMSO, Ethyl Acetate, Methanol
• PKA: 0.35±0.70(Predicted)
• CAS DataBase Reference: ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE(70458-94-5)
• EPA Substance Registry System: ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE(70458-94-5)

Safety Data

• Hazardous Substances Data: 70458-94-5(Hazardous Substances Data)

Usage

Uses

7-?Chloro-?1-?ethyl-?6-?fluoro-?1,?4-?dihydro-?4-?oxo-3-?quinolinecarboxylic Acid Ethyl Ester (Norfloxacin Impurity 5) is an impurity of Norfloxacin (N681000), an antibacterial agent and a contaminant of emerging concern (CECs).

Upstream product

• 86393-34-2 2,4-dichloro-5-fluorobenzoyl chloride 
• 74-96-4 ethyl bromide 
• 70458-93-4 7-Chloro-6-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester 

Downstream Products

• 68077-27-0 Norfloxacin hydrochloride 
• 81530-83-8 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 70458-99-0 1-ethyl-6-fluoro-7-(4-benzylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 74011-41-9 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-<4-(p-aminobenzyl)-1-piperazinyl>quinoline-3-carboxylic acid 
• 70458-97-8 7-(4-allylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 70458-96-7 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid 
• 70458-92-3 Pefloxacin 
• 74011-39-5 1-ethyl-1,4-dihydro-6-fluoro-7-[4-(p-nitrobenzyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic acid 
• 75001-81-9 7-(4-Benzoyl-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 74011-42-0 Oxonorfloxacin 
• 75001-82-0 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline 
• 74011-56-6 N-acetylnorfloxacin 
• 68077-26-9 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Chemical synthesis method for norfloxacin

The invention discloses a chemical synthesis method for norfloxacin. The chemical synthesis method comprises the following steps: (1) synthesis of a compound ethyl quinolinate: 3-ethylamino-2-(2,4-dichloro-5-fluorobenzoyl) ethyl acrylate is dissolved in DMF, potassium carbonate is added, the mixture is heated to 50-80 DEG C, reacts and stands overnight, a product is cooled and poured into cold water, produced solids are filtered, solids are washed with a large amount of water, and the product ethyl quinolinate is obtained; (2) synthesis of a compound quinolinic acid: ethyl quinolinate is dissolved in methanol, hydrochloric acid is added in a ratio being 1:1, reflux is performed for 2 h, white solids are precipitated and filtered, a filter product is washed with water and dried in a vacuum oven for 2 h, and the product quinolinic acid is obtained. The design is reasonable, and one novel norfloxacin synthesis method is selected and has good market application value.

7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

7-(substituted)piperazinyl-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acids, the pharmacologically acceptable salts thereof, compositions containing them, processes and intermediates for producing them, and methods of using them to treat bacterial infections in warm-blooded animals.