70458-95-6

Basic information

• Product Name: Pefloxacin mesylate
• Synonyms: AKOS 91194;1-ETHYL-6-FLUORO-7-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID;3-carboxy-1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxoquinoline monomethanesulphonate;Pefloxacine Mesylate;PEFLOXACIN MESYLATE, HIGH PURITY;3-quinolinecarboxylic acid,1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-,monomethanesulfonate, dihydrate;1-Ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monomethanesulfonate;Pefloxacin mesylate
• CAS NO: 70458-95-6
• Molecular Formula: CH₃O₃S*C₁₇H₂₁FN₃O₃
• Molecular Weight: 333.36
• EINECS: 274-613-9
• Product Categories: Pharmacutical raw materials;Inhibitors
• Mol File: 70458-95-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 529.1 °C at 760 mmHg
• Flash Point: 273.8 °C
• Appearance: /
• Density: 1.32 g/cm3
• Vapor Pressure: 5.05E-12mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: Freely soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in methylene chloride.
• CAS DataBase Reference: Pefloxacin mesylate(CAS DataBase Reference)
• NIST Chemistry Reference: Pefloxacin mesylate(70458-95-6)
• EPA Substance Registry System: Pefloxacin mesylate(70458-95-6)

Safety Data

• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45
• Hazardous Substances Data: 70458-95-6(Hazardous Substances Data)

Usage

Description

Pefloxacin mesylate is a broad-spectrum, third generation quinolone antibacterial agent useful in the treatment of infections due to a variety of organisms, including methicillin-resistant S. aureus. A major metabolite of pefloxacin is norfloxacin.

Chemical Properties

Pale Beige Solid

Originator

Roger Bellon (Rhone-Poulenc) (France)

Uses

Different sources of media describe the Uses of 70458-95-6 differently. You can refer to the following data:
1. Pefloxacin mesylate is a synthetic chemotherapeutic agent and an antibacterial agent with IC50 of 6.7 nM.
2. Pefloxacin is a fluorinated quinolone antibacterial; analog of Norfloxacin.

Brand name

PEFLACINE

InChI:InChI=1/C17H20FN3O3.CH4O3S/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4)

Synthetic route

potassium tetrachloroplatinate(II) (10025-99-7) + Peflox (70458-95-6) → bis{4-(3-carboxy-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolyl)-1-methylpiperazinium} tetrachloroplatinate(II) dihydrate

Conditions	Yield
With H2O In water room temp.; filtration, washing, drying;

1H-imidazole (288-32-4) + cobalt(II) chloride hexahydrate + Peflox (70458-95-6) → C20H27ClCoFN5O5

Conditions	Yield
With sodium hydroxide In water for 2h; Reflux;

1H-imidazole (288-32-4) + copper(II) choride dihydrate + Peflox (70458-95-6) → C20H23ClCuFN5O3*2.5H2O

Conditions	Yield
With sodium hydroxide In water for 2h; Reflux;

1H-imidazole (288-32-4) + nickel(II) chloride hexahydrate + Peflox (70458-95-6) → C20H23ClFN5NiO3*H2O

Conditions	Yield
With sodium hydroxide In water for 2h; Reflux;

1H-imidazole (288-32-4) + chromium(III) chloride hexahydrate + Peflox (70458-95-6) → C20H25Cl2CrFN5O4

Conditions	Yield
With sodium hydroxide In water for 2h; Reflux;

1H-imidazole (288-32-4) + Peflox (70458-95-6) + zinc(II) chloride (7646-85-7) → C20H27ClFN5O5Zn*0.25H2O

Conditions	Yield
With sodium hydroxide In water for 2h; Reflux;

1H-imidazole (288-32-4) + manganese(II) chloride tetrahydrate + Peflox (70458-95-6) → C20H23ClFMnN5O3

Conditions	Yield
With sodium hydroxide In water for 2h; Reflux;

1H-imidazole (288-32-4) + Peflox (70458-95-6) + silver nitrate → [Ag(pefloxacin)(imidazole)].2H2O

Conditions	Yield
With sodium hydroxide In water for 2h; Reflux;

Peflox (70458-95-6) + palladium dichloride → Pd(PFX)2

Conditions	Yield
With ammonia In methanol for 6h; pH=9; Reflux;