70470-07-4

Upstream product

• 64285-06-9 (+/-)-Anatoxin A 
• 111964-07-9 9-(p-tolylsulphonyl)-9-azabicyclo<4.2.1>nonan-2-one 
• 112009-95-7 cis-1-(t-butoxycarbonyl)-5-vinylproline ethyl ester 
• 112009-90-2 ethyl 2-benzylideneaminohepta-5,6-dienoate 
• 133038-46-7 ethyl 2-(methoxycarbonylamino)hepta-5,6-dienoate 
• 112009-92-4 ethyl 2-aminohepta-5,6-dienoate 
• 92844-77-4 hexahydro-9-(2-methyl-1,3-dioxolan-2-yl)-2,7-methano-2H-pyrrolo<1,2-b>-<1,2>-oxazin-3-ol methanesulfonate (ester) 
• 92844-76-3 hexahydro-3-hydroxy-2,7-methano-2H-pyrrolo<1,2-b>-<1,2>-oxazin-9-yl methyl ketone 
• 103763-34-4 hexahydro-3-hydroxy-2,7-methano-2H-pyrrolo<1,2-b>-<1,2>-oxazin-9-yl methyl ketone ethylene ketal 
• 92844-78-5 2-(2-methyl-1,3-dioxolan-2-yl)-2-azabicyclo<4.2.1>-nonan-3-ol 
• 90741-53-0 t-butyl-1-(9-azabicyclo<4.2.1>-non-2-ene-2-yl)ethanone carbamate 
• 107970-41-2 ethyl 2-(p-tolylsulphonylamino)hepta-5,6-dienoate 
• 111964-04-6 cis-(p-tolylsulphonyl)-5-vinylproline ethyl ester 
• 133038-54-7 cis-5-(2-hydroxyethyl)-1-(p-tolylsulphonyl)proline ethyl ester 

Relevant academic research and scientific papers

Investigation of a unified strategy for the synthesis of anatoxin analogues: Scope and limitations

Syntheses of the potent neurotoxins and biochemical probes anatoxin-a and homoanatoxin and several analogues by a combined two-directional synthesis-tandem reaction strategy are presented. Key steps include an oxidative desymmetrisation and a tandem Micha

A two-directional approach to the anatoxin alkaloids: Second synthesis of homoanatoxin and efficient synthesis of anatoxin-a

Total syntheses of the potent neurotoxins, environmental hazards, and biochemical probes anatoxin-a and homoanatoxin have been achieved from a common intermediate using a combined two-directional synthesis-tandem reaction strategy which includes key advan

Synthetic and Stereochemical Studies Directed Towards Anatoxin-a

The synthesis and stereocontrolled Ag1-catalysed cyclisation of a series of allenic amino esters 8a-e is described.For compounds 8a-d the cis-2,5-disubstituted pyrrolidine 9 is formed exclusively but the primary amine 8e undergoes cyclisation n

The use of nitrones in the synthesis of anatoxin-a, very fast death factor

The synthesis of anatoxin-a (1) was completed by using the cycloaddition of 1-pyrroline-1-oxide (2) onto dienol (6), a reaction which proceeded with high stereoselectivity, regioselectivity, and site selectivity. The resultant adduct (i.e. 7) was oxidized to a second nitrone (i.e. 8) which undergoes a second closure to afford cycloadduct 9a with regiospecificity. The conversion of 9a into anatoxin-a hydrochloride (1 · HCl) was both direct and efficient.