70485-99-3Relevant academic research and scientific papers
LDA-Promoted Synthesis of 3-Amino Furans by Selective Lithiation of Enaminones
Kong, Lingkai,Shao, Yushang,Li, Yanli,Liu, Yuanyuan,Li, Yanzhong
, p. 12641 - 12645 (2016/01/09)
An efficient cascade β-metalation/addition/cyclization reaction promoted by LDA is described in which 3-amino furans were constructed from enaminones and aldehydes. A broad range of substituents on the starting compounds was tolerated, and the polysubstit
Synthesis of the naphthalenone, dihydroquinoline, and dihydrofuran derivatives
Guengoer, Fuesun Seyma,Anac, Olcay,Sezer, Oezkan
, p. 1115 - 1129 (2011/08/05)
The reactions of enaminones with dimethyl diazomalonate were investigated in the presence of copper(II) acetylacetonate. From the reaction of (E)-3-[methyl(phenyl)amino]-1-phenylprop-2-en-1-one (6c), dimethyl 2-[methyl(phenyl)amino]-4-oxonaphthalene-1,1-(4H)-dicarboxylate, was unexpectedly obtained as the major product. Quinoline derivatives were formed as the major products in the case of N-methyl-p-anisidino and N-methyl-p-toluidino enaminones. The reactions of acetyl enaminones were also realized, and quinoline derivatives were isolated as the major products. 3H- and 5H-dihydrofurans were also formed as side products in these reactions. These results differ from those reported earlier on the reactions of tertiary enaminones with carbenes/metal carbenes.
