705-02-2

Usage

Uses

Used in Pharmaceutical Industry:
(2-FLUOROPHENYL)THIO]ACETIC ACID is used as a key intermediate in the synthesis of phenylsulfanylalkylcarboxylic acid compositions. These compositions are valuable for the delivery of active agents, which can be utilized in the development of pharmaceuticals targeting various diseases and conditions. The presence of the fluorine atom in the molecule can potentially enhance the lipophilicity and metabolic stability of the resulting compounds, thereby improving their pharmacokinetic properties and therapeutic efficacy.

InChI:InChI=1/C8H7FO2S/c9-6-3-1-2-4-7(6)12-5-8(10)11/h1-4H,5H2,(H,10,11)/p-1

Upstream product

• 124-38-9 carbon dioxide 
• 655-20-9 2-fluorothioanisole 
• 2557-78-0 2-fluorothiophenol 
• 79-11-8 chloroacetic acid 
• 68-11-1 mercaptoacetic acid 
• 348-54-9 2-Fluoroaniline 

Downstream Products

• 2557-78-0 2-fluorothiophenol 
• 298-12-4 Glyoxilic acid 

Relevant academic research and scientific papers

RETRACTED ARTICLE: Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases

A series of thiochromeno[2,3-c]quinolin-12-one derivatives with various substitutions were synthesized and evaluated as topoisomerase (Topo) inhibitors. Six (8, 10, 12, 14, 19, and 26) of 23 compounds showed strong inhibitory activities against Topo-media

FMS-LIKE TYROSINE KINASE INHIBITORS

The present invention relates to Fms-like tyrosine kinase (FLT3) inhibitors. The present invention provides novel 4-quinolinone derivatives used as FLT3 inhibitors and for treatment and/or prevention of tumors.

ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.

KINETICS AND MECHANISM OF OXIDATION OF (ARYLTHIO)ACETIC ACIDS BY PYRIDINIUM HYDROBROMIDE PERBROMIDE

Oxidation of several monosubstituted (phenylthio)acetic acids (PTAA) by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid.The reaction is first order with respect to PHPB.Michaelis-Menten type kinetics are observed with respect to (arylthio)acetic acid.The effect of solvent composition indicates that the transition state is more polar than the reactants.The formation constants of the intermediate substrate-PHPB complexes and the rates of their decomposition were determined at different temperatures.The rates of oxidation of para and meta-substituted (phenylthio)acetic acids were correlated with Hammett's substituent constants.The ρ value is -1.60 at 35 deg c.The rates of oxidation of ortho substituted compounds are correlated with Charton's triparametric equation.A mechanism involving the decomposition of the intermediate complex in the slow rate-determining step affording a sulphonium ion which hydrolyses in a subsequent fast step to the sulphoxide is proposed.

Metalation reactions. XV. Regioselective metalation of (alkylthio)fluorobenzene

In reactions of (alkylthio)fluorobenzenes with n-butyllithium the compounds 4-RSC6H4F (R = Me, iPr) and 2-iPrSC6H4F were found to undergo metalation selectively ortho to the fluorine atom, whereas 2-MeSC6H4F undergoes metalation at the thiomethyl carbon atom.