705-06-6

Usage

Uses

Used in Organic Synthesis:
1-Butylpyrimidine-2,4(1H,3H)-dione is used as a building block in organic synthesis for the creation of other organic compounds. Its unique chemical structure allows it to be a versatile component in the synthesis of various molecules.
Used in Pharmaceutical Industry:
1-Butylpyrimidine-2,4(1H,3H)-dione is used as a pharmaceutical intermediate, playing a crucial role in the development of new drugs. Its properties make it a valuable precursor in the synthesis of pharmaceuticals with potential therapeutic applications.
Safety Considerations:
It is important to handle and store 1-butylpyrimidine-2,4(1H,3H)-dione safely, as it may be harmful if ingested, inhaled, or comes into contact with skin or eyes. Proper safety measures should be taken during its use to minimize any potential risks.

Upstream product

• 7424-91-1 methyl 3,3-dimethoxypropionate 
• 592-31-4 1-butyl-urea 
• 41365-74-6 3,3-diethoxypropionic amide 
• 111-36-4 n-butyl isocyanide 
• 109-65-9 1-bromo-butane 
• 66-22-8 uracil 
• 71-36-3 butan-1-ol 

Downstream Products

• 905854-83-3 N³-benzoyl-N¹-n-butyl-5-iodouracil 
• 905854-85-5 3-benzoyl-1-butyl-5-[2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-[1,3]dithiol-4-yl]-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Hydrogen-bonded charge-transfer complexes of TTF containing a uracil moiety: Crystal structures and electronic properties of the hydrogen cyananilate and TCNQ complexes

(matrix presented) A novel TTF-based donor with a uracil moiety, TTF-(1-n-butyluracil-5-yl) (TnbU), was synthesized. Crystal structures of both TnbU and the charge-transfer complex of TnbU-hydrogen cyananilate possess complementary double hydrogen bonds t

Highly efficient protocol for one-pot N-alkylation of nucleobases using alcohols in bmim[Br]: A rapid route to access acyclic nucleosides

Highly efficient protocol for one-pot N-alkylation of nucleobases using alcohol in ionic liquid media as a straightforward route to access acyclic nucleoside was described. In this protocol purine, pyrimidine as well as azole derivatives underwent the N-a

Water-induced gel formation of an oleanlic acid-adenine conjugate and the effects of uracil derivative on the gel stability

The conjugate of oleanlic acid with adenine was synthesized and it could be gelled in mixed solvents of THF and water, but no gel was formed in the single organic solvent. The self-aggregation behaviour and physical properties of the organogel were characterized by 1H NMR, FT-IR, and scanning electron microscopy. The morphology and the stability of the gel were remarkably affected by the uracil derivative through destroying hydrogen-bonding.

Protons as the triggers to regulate hydrogen-bonding receptors

(equation presented) The protonation of alkylamines in two novel receptors results in intramolecular host-guest associations between the resulting ammonium ions and crown ether macrocycles. These interactions result in conformational changes of the receptors and prevent them from acting as hydrogen bond complements for uracil and carboxylate guest species.

Improved One-Step Procedure for the Preparation of 1-Substituted and 1,3-Disubstituted Uracils and 2-Thiouracils

A convenient one-pot procedure for the synthesis of 1-substituted and 1,3-disubstituted uracils and 2-thiouracils consists of acylation of ureas or thioureas with methyl 3,3-dimethoxypropanoate in the presence of a strong base, and acidic work-up.The yields range from 36 to 99percent.In all cases, only one regioisomer is isolated.

Fluoride ion catalyzed alkylation of purines, pyrimidines, nucleosides and nucleotides using alky halides.

Alkyl halides react rapidly with purines and pyrimidines in the presence of fluoride ion. Alkylation of thymidine leads to novel dimeric nucleoside derivatives bridged through N3. Alkylation of thymidine mono and dinucleotides leads to alkylation at the base (N3) as well as diester and triester formation at the phosphate.