70502-87-3

Basic information

• Product Name: Benzenethiol, 3-amino-4-chloro-
• Synonyms: 4-Chlor-3-amino-thiophenol;3-amino-4-chlorothiophenol;4-Chlor-3-amino-phenylmercapton;4-chloro-3-amino-thiophenol;2-chloro-5-mercaptoaniline
• CAS NO: 70502-87-3
• Molecular Formula: C6H6ClNS
• Molecular Weight: 159.639
• Mol File: 70502-87-3.mol

Chemical Properties

• CAS DataBase Reference: Benzenethiol, 3-amino-4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenethiol, 3-amino-4-chloro-(70502-87-3)
• EPA Substance Registry System: Benzenethiol, 3-amino-4-chloro-(70502-87-3)

Safety Data

• Hazardous Substances Data: 70502-87-3(Hazardous Substances Data)

Upstream product

• 97-08-5 3-nitro-4-chlorosulfonyl chloride 

Downstream Products

• 917894-06-5 2-chloro-5-S-benzyl-thioaniline 
• 1073435-76-3 2-Chloro-5-(1-methyl-1-phenylethylthio)aniline 
• 1220982-13-7 2-chloro-5-((2-fluoroethyl)mercapto)aniline 
• 1349064-27-2 1,1’-(disulfanediylbis(6-chloro-1,3-phenylene))bis(3-methyl-3-(3-(methylthio)phenyl)guanidine) 
• 917894-08-7 N-(5-benzylthio-2-chlorophenyl)-N'-(3-methylthiophenyl)-N'-methyl-guanidine hydrochloride 
• 917894-09-8 N-(2-chloro-5-mercaptophenyl)-N'-(3-methylthiophenyl)-N'-methyl-guanidine hydrochloride 
• 917894-07-6 2-chloro-5-S-benzyl-thioaniline hydrochloride 
• 917894-11-2 N-(2-chloro-5-(S-2-fluoroethyl)thiophenyl)-N'-(3-methylthiophenyl)-N'-methyl guanidine 
• 917894-05-4 N-(2-chloro-5-fluoromethylthiophenyl)-N'-(3-methylthiophenyl)-N'-methyl-guanidine 
• 917894-23-6 N-(2-chloro-5-mercaptophenyl)-N'-methyl-N'-(3-thiomethylphenyl)guanidine 

Relevant articles and documents

Development of an automated, GMP compliant FASTlab radiosynthesis of [18F]GE-179 for the clinical study of activated NMDA receptors

N-(2-chloro-5-(S-2-[18F]fluoroethyl)thiophenyl)-N'-(3-thiomethylphenyl)-N'-methylguanidine, ([18F]GE-179), has been identified as a promising positron emission tomography (PET) ligand for the intra-channel phencyclidine (PCP) binding

SUBSTITUTED PHENYLPIPERAZINE COMPOUND AND PEST CONTROL AGENT

PROBLEM TO BE SOLVED: To provide a pest control agent for controlling harmful organisms in agricultural and horticultural fields or harmful organisms to an animal such as a pet and a domestic animal or a domestic animal. SOLUTION: There is provided a substituted phenyl-piperazine compound represented by the following formula (1) or a salt thereof. (wherein, A represents an alkyl group having 1 to 20 carbon atoms which may be substituted or the like; R represents an alkyl group having 1 to 20 carbon atoms which may be substituted or the like; X represents an alkyl having 1 to 6 carbon atoms which may be substituted with a halogen atom, a cyano group or the like; Y represents a halogen atom and an alkyl group having 1 to 6 carbon atoms which may be substituted; m represents any one of integers of 0 to 4; n represents any one of integers of 0 to 8; p represents any one of integers of 0 to 2; and q and r represent any one of integers of 0 to 1.) COPYRIGHT: (C)2015,JPO&INPIT

N′-3-(Trifluoromethyl)phenyl Derivatives of N-Aryl-N′-methylguanidines as Prospective PET Radioligands for the Open Channel of the N-Methyl- d -aspartate (NMDA) Receptor: Synthesis and Structure-Affinity Relationships

N-Methyl-d-aspartate (NMDA) receptor dysfunction has been linked to several neuropsychiatric disorders, including Alzheimer's disease, epilepsy, drug addiction, and schizophrenia. A radioligand that could be used with PET to image and quantify human brain NMDA receptors in the activated "open channel" state would be useful for research on such disorders and for the development of novel therapies. To date, no radioligands have shown well-validated efficacy for imaging NMDA receptors in human subjects. In order to discover improved radioligands for PET imaging, we explored structure-affinity relationships in N′-3-(trifluoromethyl)phenyl derivatives of N-aryl-N′-methylguanidines, seeking high affinity and moderate lipophilicity, plus necessary amenability for labeling with a positron-emitter, either carbon-11 or fluorine-18. Among a diverse set of 80 prepared N′-3-(trifluoromethyl)phenyl derivatives, four of these compounds (13, 19, 20, and 36) displayed desirable low nanomolar affinity for inhibition of [3H](+)-MK801 at the PCP binding site and are of interest for candidate PET radioligand development.

Synthesis and in vitro evaluation of 18F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET

Two S-[18F]fluoroalkylated diarylguanidines were synthesized and evaluated in vitro as potential tracers for imaging of N-methyl-d-aspartate receptors (NMDARs) with positron emission tomography (PET). [18F]1 and [18F]10 we

NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES

[Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. [Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; RA and RB are independently halogen, cyano, alkyl, alkylsulfonyl, -OW1, -SW1, -COW2, -NW3W4, -SO2NW3W4, aryl, etc.; RC is H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, -CO-Y, -SO2-Y -S-(alkylene)-Y, -O-(alkylene)-Y, -SO2-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.

IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES

The invention provides a compound of formula (I); or a salt or solvate thereof, wherein: R1 is hydrogen or C1-4alkyl; R2 and R4 are each independently selected from C1-4 alkyl, [11C] C1 4alkyl, and [18F]-C1-4 fluoroalkyl provided that at least one of R2 and R4 is [11C] C1 4alkyl or [18F]-C1-4 fluoroalkyl; and R3 is halo. Such compounds having use for imaging central nervous system receptors.