1349064-27-2

Upstream product

• 70502-87-3 3-amino-4-chlorobenzenethiol 
• 1783-81-9 3-methylmercaptoaniline 
• 458567-42-5 N-(3-(methylthio)phenyl)cyanamide 
• 71205-41-9 1-(3-(methylthio)phenyl)thiourea 
• 222734-73-8 N-methyl-N-(3-(methylthio)phenyl)cyanamide 
• 97-08-5 3-nitro-4-chlorosulfonyl chloride 

Downstream Products

• 917894-23-6 N-(2-chloro-5-mercaptophenyl)-N'-methyl-N'-(3-thiomethylphenyl)guanidine 
• 917894-11-2 N-(2-chloro-5-(S-2-fluoroethyl)thiophenyl)-N'-(3-methylthiophenyl)-N'-methyl guanidine 

Relevant academic research and scientific papers

Synthetic method of [18F]-GE-179

The invention discloses a [18F]-GE-179 synthesis method, which comprises: step 1, generating H protons by a cyclotron to bombard 18O heavy oxygen water, generating 18F ions by using a nuclearreaction 18O(p, n)18F; enriching the 18F ions throug

Development of an automated, GMP compliant FASTlab radiosynthesis of [18F]GE-179 for the clinical study of activated NMDA receptors

N-(2-chloro-5-(S-2-[18F]fluoroethyl)thiophenyl)-N'-(3-thiomethylphenyl)-N'-methylguanidine, ([18F]GE-179), has been identified as a promising positron emission tomography (PET) ligand for the intra-channel phencyclidine (PCP) binding

ALKYLATION METHOD

The present invention relates to a method of radiochemical synthesis which is useful in the synthesis of a positron emission tomography (PET) tracer.

METHOD OF SYNTHESIS

The present invention provides a method for the preparation of a radiolabeiied guanidine derivative, in particular wherein the radiolabeiied guanidine derivative is a positron emission tomography (PET) tracer. Certain intermediates useful in said method a