70526-40-8

Upstream product

• 64-17-5 ethanol 
• 2283-08-1 2-hydroxy-1-naphthalenecarboxylic acid 
• 38256-56-3 1-(2-bromo-ethyl)-2-bromomethyl-benzene 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 3144-47-6 6-hydroxybenzocyclohepten-7-one 
• 18698-97-0 ortho-bromophenylacetic acid 
• 71-41-0 pentan-1-ol 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 16061-73-7 3-(2-cyanomethylphenyl)propionitrile 
• 183734-98-7 3-(2-carboxymethylphenyl)acrylic acid 

Downstream Products

• 143260-87-1 3-(2-ethoxycarbonylmethyl-phenyl)-propionic acid ethyl ester 
• 70526-41-9 Methyl-o-(2-carbomethoxymethyl)phenylacetat 
• 5020-62-2 (4-indanyl)acetic acid 
• 70526-48-6 4--butyl-1,1-d2-dimethylamin 
• 18811-45-5 o-(3-Carbomethoxy-propyl)-hydrozimtsaeure-methylester 
• 857578-99-5 1-(2-chloro-ethyl)-2-(3-chloro-propyl)-benzene 
• 70526-45-3 4-buttersaeure 
• 70526-44-2 4-[2-(2-cyano-ethyl)-phenyl]-butyronitrile 
• 70650-67-8 4-(o-Allyl-3,3-d2-phenyl)-1-buten-1,1-d2 
• 70526-43-1 1-(3-Brompropyl)-2-(2-bromethyl)benzol 
• 70526-42-0 2-(3-hydroxy-propyl)-phenethyl alcohol 
• 39967-37-8 4-(o-Allylphenyl)-1-buten 
• 193814-15-2 2-(2,4-diethoxycarbonylimidazol-1-yl)-4-benzenesulphonamidocarbonylmethylindan-1-one 
• 193814-14-1 9-(2-benzenesulfonylamino-2-oxo-ethyl)-4-oxo-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazine-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

RPR 119990, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: Synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonists are of potential interest for the treatment of certain acute and chronic neurodegenerative diseases, including amyotrophic lateral sclerosis. Here, we describe the

Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action

A novel series of 2- and 9-disubstituted heterocyclic-fused 4-oxo-indeno[1,2-e]pyrazin derivatives was synthesized. One of them, the 9-(1H-tetrazol-5-ylmethyl)-4-oxo-5,10-dihydroimidazo[1,2-a]indeno[1,2-e]pyraz in-2-yl phosphonic acid 4i exhibited a stron

Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]indeno[1,2-e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists

The over-stimulation of excitatory amino acid receptors such as the glutamate AMPA receptor has been suggested to be associated with neurodegenerative disorders. Here we describe an original series of readily water soluble 4-oxo-imidazo[1,2-a] indeno[1,2-

5H, 10H-IMIDAZO[1,2-A]INDENO[1,2-E] PYRAZIN-4-ONE DERIVATIVES, PREPARATION THEREOF, AND DRUGS CONTAINING SAID DERIVATIVES

Compounds of formula (I), wherein R is a hydrogen atom or a carboxy, alkoxycarbonyl,--CO--NR 4 R 5,--PO 3 H 2 or--CH 2 OH radical, and R 1 is an-alk-NH 2,-alk-NH--CO--R 3,-alk-COOR 4,-alk-CO--NR 5 R 6 or--CO--NH--R 7 radical. The compounds of formula (I) have valuable pharmacological properties and are antagonists of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor also known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive antagonists of the N-methyl-D-aspartame (NMDA) receptor and more specifically are ligands for NMDA receptor glycine modulator sites.

Aromatic Spiranes, XXII [1]: Preparation of Cyclopenteno-4,5-indan-1-one and 2-Carbomethoxy- and 4-Chloromethyl-indane as Synthones for the Syntheses of Anellated 2,2′-Spirobiindanone

The title compounds were prepared as follows: tert.-butyl-indane (10) was formylated to give a 72:28 mixture of the aldehydes 23a and 23b which were submitted to a Knoevenagel-Doebner condensation to afford the cinnamonic acids 24. From the mixture, the p