70526-40-8Relevant articles and documents
RPR 119990, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: Synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis
Canton, Thierry,Boehme, Georg Andrees,Boireau, Alain,Bordier, Francoise,Mignani, Serge,Jimonet, Patrick,Jahn, Ghafoor,Alavijeh, Mohammad,Stygall, James,Roberts, Simon,Brealey, Clive,Vuilhorgne, Marc,Debono, Marc-William,Le Guern, Sylvain,Laville, Michel,Briet, Dominique,Roux, Michel,Stutzmann, Jean-Marie,Pratt, Jeremy
, p. 314 - 322 (2007/10/03)
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonists are of potential interest for the treatment of certain acute and chronic neurodegenerative diseases, including amyotrophic lateral sclerosis. Here, we describe the
Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]indeno[1,2-e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists
Pratt, Jeremy,Jimonet, Patrick,Bohme, Georg Andrees,Boireau, Alain,Damour, Dominique,Debono, Marc Williams,Genevois-Borella, Arielle,Randle, John C.R,Ribeill, Yves,Stutzmann, Jean-Marie,Vuilhorgne, Marc,Mignani, Serge
, p. 2749 - 2754 (2007/10/03)
The over-stimulation of excitatory amino acid receptors such as the glutamate AMPA receptor has been suggested to be associated with neurodegenerative disorders. Here we describe an original series of readily water soluble 4-oxo-imidazo[1,2-a] indeno[1,2-
Aromatic Spiranes, XXII [1]: Preparation of Cyclopenteno-4,5-indan-1-one and 2-Carbomethoxy- and 4-Chloromethyl-indane as Synthones for the Syntheses of Anellated 2,2′-Spirobiindanone
Melmer,Neudeck
, p. 275 - 290 (2007/10/03)
The title compounds were prepared as follows: tert.-butyl-indane (10) was formylated to give a 72:28 mixture of the aldehydes 23a and 23b which were submitted to a Knoevenagel-Doebner condensation to afford the cinnamonic acids 24. From the mixture, the p