70540-62-4Relevant academic research and scientific papers
Synthesis of new oxadiazole, triazole and oxazepine derivatives of quinazoline moiety
Essa, Fadhel Omran,Al-Hamdani, Kadhum J.K.
, p. 1706 - 1710 (2018/07/10)
New 2-(4-oxo-2-phenylquinazolin-3(4H)-yl)-3-phenyl propanoic acid derivatives have been prepared by reaction of 2-phenyl-4H-1,3-benzoxazin-4-one with phenylalanine. The reaction of compound 1 with thionyl chloride produced 2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoyl chloride (2). Condensation of compound 2 with hydrazine hydrate afforded 2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenyl propane hydrazide (3). The reaction of compound 3 with carbon disulfide and potassium hydroxide yielded 3-[1-(5-mercapto-1,3,4-oxadiazol-2-yl)-2-phenylethyl]-2-phenylquinazolin-4(3H)-one (4). Teratment of compound 4 with hydrazine hydrate gave 3-[1-(5-mercapto-4H-1,2,4-triazol-3-yl)-2-phenylethyl]-2-phenylquinazolin- 4(3H)-one (5). The reaction of compound 3 with phenyl isothiocyanate resulted in formation of 2-[2-(2-phenyl-4-oxoquinazolin-3(4H)-yl)-3-phenylpropanoyl] hydrazine carbothioamide (6). Treatment of compound 6 with aqueous sodium hydroxide solution produced 3-[1-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-2-phenylethyl]2-phenylquinazolin-4(3H)-one (7). The azomethines 8a-d were synthesized from the reaction between the corresponding aldehydes and acid hydrazide 3. Moreover, N-(3-methyl-1,5-dioxobenzo[e][1,3]oxazepin-4(1H,3H,5H)-yl-2-(4-oxo-2-phenyl quinazoline-3(4H)-yl)acetamide 9a-d were synthesized from the cyclic condensation of imines with phthalic anhydride. The structure of novel synthesized compounds were suggested from IR,1H NMR and and13C NMR spectral studies.
Synthesis and study of modified polyvinyl alcohol containing amino acid moieties as anticancer agent
Samir, Ali H.,Saeed, Ruwaidah S.,Matty, Fadhel S.
, p. 286 - 294 (2018/03/21)
A series of new phthalimides compounds[3-7]a-i were synthesized from reaction of Malic anhydride, phthalic anhydride, nitro phthalic anhydride, 2-phenyl-4H-benzo[d][1,3]oxazin-4-one, 2-(4-nitrophenyl)-4H-benzo[d][1,3]oxazin-4-one with different amino acids as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tyrosine and Phenyl alanine [1]a-i under fusion conditions. Compounds [3-7]a-i react with SOCl2 in the presence of benzene to produce compounds [8-12]a-i. Chemical modification of Poly(vinyl alcohol)were obtained by reaction of PVA with compounds [8-12]a-i using the dimethyl formamide to give compounds [13-17]a-i. The structure of the synthesized compounds was characterized by their analytical and spectral data as, IR spectra, 1H, 13C-NMR, Elemental analysis (CHN), UV-Vis Spectroscopy, Scanning electron microscopy (SEM), Antibacterial activity were screened via two kinds of bacteria. Also, anticancer activity were examined for most of the modified polyvinyl alcohol.
