70550-16-2

Basic information

• Product Name: 5-acetyl-2-cyclohexen-1-one
• Synonyms: 5-acetyl-2-cyclohexen-1-one
• CAS NO: 70550-16-2
• Molecular Weight: 138.166
• Mol File: 70550-16-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-acetyl-2-cyclohexen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-acetyl-2-cyclohexen-1-one(70550-16-2)
• EPA Substance Registry System: 5-acetyl-2-cyclohexen-1-one(70550-16-2)

Safety Data

• Hazardous Substances Data: 70550-16-2(Hazardous Substances Data)

Upstream product

• 79378-41-9 5-acetyl-2-cyclohexen-1-ol 
• 19977-37-8 methanesulfinic acid 4-methyl-anilide 
• 56917-70-5 5-(trimethylsilyl)cyclohex-3-enone 
• 75-36-5 acetyl chloride 
• 18407-84-6 1-methoxy-3,6-bis(trimethylsilyl)cyclohexa-1,4-diene 

Downstream Products

• 121-71-1 3-Hydroxyacetophenone 

Relevant articles and documents

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A new method for the meta acylation of anisole and its para-methyl or fluoro derivatives, is described. Addition of two trimethysilyl groups in the 2 and 5 positions (relative to the methoxy group), followed by hydrolysis affords the corresponding 5-trimethylsilyl-3-cyclohexenones. Electrophilic substitution of the silyl group using RCOC1/2AlCl3 at low temperature provides, after final aromatisation promoted by Pd/C or CuBr2/LiBr, the expected meta acylated products. This mode of meta functionalization has been successfully applied to an original synthesis of ketoprofen starting from anisole.