70565-65-0Relevant academic research and scientific papers
Reduction of α-Trialkylsiloxy Nitriles with Diisobutylaluminium Hydride (DIBAH): A Facile Preparation of α-Trialkylsiloxy Aldehydes and their Derivatives
Hayashi, Masahiko,Yoshiga, Tomoko,Nakatani, Kanako,Ono, Kazuyuki,Oguni, Nobuki
, p. 2821 - 2830 (2007/10/02)
The stepwise synthesis of α-trimethylsiloxy aldehydes and α-hydroxy aldehydes could be achieved via the reduction of α-trimethylsiloxy nitriles with diisobutylaluminium hydride (DIBAH) starting from a variety of ketones.The facile synthesis of optically active α-tert-butyldimethylsiloxy aldehydes was attained by combination of asymmetric silylcyanation of aldehydes and DIBAH reduction of optically active α-siloxy nitriles.Furthermore, in the reduction of some α-tert-butyldimethylsiloxy-β,γ-unsaturated nitriles, migration of the double bond took place to form more stable α-siloxy-α,β-unsaturated aldehydes under some reaction conditions.
Synthesis of Carbon and Phosphorus Esters of α-Fluoro Alcohols
Vinson, Wayne A.,Prickett, Kathryn S.,Spahic, Bojana,Montellano, Paul R. Ortiz de
, p. 4661 - 4668 (2007/10/02)
Carbon and phosphorus esters of α-fluoro alcohols are promising functions for the construction of suicide substrates for esterases, phosphatases, and other enzymes.A route for the synthesis of substrates incorporating these hitherto inaccessible functiona
