70588-46-4

Upstream product

• 76620-26-3 sodium salt of (E)-1-phenyl-3-penten-1-one N-tosylhydrazone 
• 211105-80-5 (E)-1-(3,5-dimethyl-1H-pyrazol-1-yl)but-2-en-1-one 
• 98-86-2 acetophenone 
• 55177-38-3 1-[(1E)-1-methyl-1,3-butadienyl]benzene 
• 57501-29-8 4-chloro-4-phenyl-pent-1-ene 
• 4743-74-2 2-phenylpent-4-en-2-ol 
• 4079-52-1 methoxymethyl phenyl ketone 
• 67-56-1 methanol 
• 88241-41-2 1-methoxy-2-phenylpent-3-yn-2-ol 
• 75761-40-9 (Z)-2-phenyl-1,3-pentadiene 
• 35660-91-4 (E)-1-phenyl-2-buten-1-one 
• 69366-39-8 dilithiated acetic acid 

Downstream Products

• 116669-44-4 r-3-methyl-1,t-4-diphenyl-c-4-<(E)-propenyl>-1-cyclohexene 
• 116780-14-4 r-3-methyl-1,c-4-diphenyl-t-4-<(E)-propenyl>-1-cyclohexene 
• 1367737-24-3 2-methyl-4-phenyl-1-oxaspiro[5.5]undec-3-ene 
• 80098-80-2 2-methyl-4-phenyl-5,6-dihydro-2H-pyran 

Relevant academic research and scientific papers

Asymmetric conjugate addition reaction using pyrazole derivatives as a chiral catalyst

The conjugate addition of Grignard reagent (2) onto 1-(α,β -unsaturated)acyl 3,5-dimethylpyrazole (1) was enantioselectively catalyzed by the copper complex from cuprous compounds and 3-phenyl-l-menthopyrazole (3).

Stereochemistry of Carbenic 1,2-Vinyl Shifts

Various 1-phenylbut-3-enylidenes, (Ph)CCR2CH=CHR', were generated thermally and photolytically from tosylhydrazone (diazo) precursors. 1,2-Vinyl shifts, leading to 1,3-dienes, R′CH=CHC(Ph)=CR2, were found to predominate over γ-C-H insertion (R = Me) and to compete with 1,2-H shifts (R = H). Intramolecular addition to the double bond was detected in the case of R = R′ = Me. The resulting bicyclobutane is thermally stable and does not mediate the vinyl shift. Stereospecific migration of 1-propenyl groups (R′ = Me), with retention of configuration, was observed on thermolysis and direct photolysis of appropriate substrates. These data exclude the intervention of a triplet diradical and point to vinyl migration in the singlet manifold. Benzophenone-sensitized generation of the carbenes led to partial stereomutation but did not provide conclusive evidence for a triplet rearrangement (isomerization of the diene products could not be avoided under these conditions).

Reactions of Propargyl Alcohols. VII. Lithium Aluminium Hydride Reductions of 1-Methoxy-2-phenylpent-3-yn-2-ol, 1 Methoxy-3-phenylhex-4-yn-3-ol and 7-Methoxy-4-phenylhept-2-yn-4-ol

Lithium aluminium hydride reductions in ether solvents of 1-methoxy-2-phenylpent-3-yn-2-ol (7a), 1-methoxy-3-phenylhex-4-yn-3-ol (7b) and 7-methoxy-4-phenylhept-2-yn-4-ol (7c) are reported.Evidence for methoxy group participation in the reduction process

Synthesis of Isomerically Pure (E)- and (Z)-1,3-Disubstituted 1,3-Dienes

The (E)-dienes 1a - p were prepared in >98percent purity by dehydrative decarboxylation of the corresponding 4,5-unsaturated 3-hydroxycarboxylic acids 3 with dimethylformamide dimethylacetal (11).The (Z)-isomers 6a - m were obtained by stereouncontrolled

Preparation and Stereochemistry of Some 1,1-Disubstituted Buta-1,3-dienes

The preparation of five (E)- and five (Z)-1,1-disubstituted buta-1,3-dienes is described and their stereochemistry assigned.The effect of the Z-E isomerism on the chemical shifts in the 13C and 1H n.m.r. spectra is discussed.